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Research: Polycystic Ovary Syndrome
(PCOS)
PCOS Studies With Open Enrollment
The following is a list of the current research studies for women with
PCOS, under the direction of Dr. Richard
Legro, at the Penn State Milton S. Hershey Medical Center
in Hershey, PA. These research studies have been approved by the Institutional Review
Board under FDA regulations at Penn State Milton S. Hershey Medical Center. Please note: if you
are interested in more than one study you do not need to fill out more than one form.
You are now on a secure site, and your
information will be transmitted securely and confidentially according to
HIPPA regulations.
Continuous Glucose monitoring in pregnant women with
Polycystic Ovary Syndrome
Are you pregnant? Pregnant women ages
19-40 without serious health problems may be eligible to
participate in a research study. The study will test
if pregnant women with Polycystic Ovary Syndrome (PCOS) are
more prone to develop gestational diabetes than pregnant
women without Polycystic Ovary Syndrome. We would like
to see you as early in your pregnancy as possible. We
will monitor your glucose levels throughout the pregnancy.
You will be asked to follow a specific meal plan during the
days the testing is performed. You will receive
compensation for participating.
For more information, please contact Barb
Scheetz at
1-800-585-9585 or 717-531-4483 or email
bscheetz@psu.edu
Study #1 Title: Genetics of PCOS (#97-041 & 94-088)
Study
Brief: A national study involving questionnaires and blood work to locate the gene for
PCOS. Eligible study participants must have 6 or fewer menses per year and
a sibling or siblings and/or a parent willing to participate. Family members will also be asked to
complete questionnaires and have blood work done at a local lab if they are eligible. Study
participants cannot be taking any hormonal medications/birth control pills to be in the
study. This study involves a hormonal evaluation to diagnose PCOS through
lab work at no
charge, which can be done via a local laboratory or at Penn State Hershey Medical Center. All
study participants will receive compensation upon completion of the study.
Contact:
Barb Scheetz, Research Coordinator at 1-800-585-9585 or 717-531-4483.
Fill out the survey for Study #1.
Study #2 Title: A six week double-blinded, randomized
trial of Atrovastatin for the treatment of PCOS women with elevated LDL
cholesterol
If you are a woman with excess hair on your
face or irregular menstrual periods, you may have
Polycistic Ovary Syndrome (PCOS). Women with PCOS may
be at higher risk for heart disease. We are
investigating whether the drug, Atrovastatin, will lower
cholesterol levels, improve the function of blood vessels,
decrease circulating male hormone levels, and improve
symptoms in women with PCOS.
You may be eligible for this research study
if you are a woman between the ages of 18 and 40 with PCOS
and LDL cholesterol greater than 100 mg/dl. a
comprehensive medical evaluation and study treatment will be
provided at no charge. Participants will also receive
monetary compensation.
For more information, please contact Barb
Scheetz at
1-800-585-9585 or 717-531-4483 or email
bscheetz@psu.edu
Study #8 Title: The Effect of Combination Therapy with
Lifestyle Intervention and Metformin in Females with PCOS (Child)
The purpose of this study is to offer your
child the opportunity to take part in a study because she has the condition
known as Polycystic Ovary Syndrome (PCOS).
PCOS is a condition that causes irregular periods, inability to get
pregnant, and excessive facial and body hair.
The United States Food and Drug Administration approve the drug used
in this study, Metformin, for the treatment of Type II diabetes. However, it is commonly used in PCOS patients because of the
inability to properly process insulin, a hormone that controls blood sugar.
This study is designed to compare the drug Metformin, combined with
exercise versus placebo (pill with no medication) combined with exercise in
females with PCOS. The study
will examine the effect of these two different combinations on the frequency
of egg release from the ovaries, hyperandrogenemia (increased levels of male
hormones), and your sensitivity to insulin.
The study involves traveling to the
Hershey Medical Center every month after an initial visit over a 6-month
period. Your child will be
assigned to one of two treatment groups.
One being Metformin combined with exercise, or placebo (pill with no
medication) combined with exercise.
The procedures that will take place at
every monthly visit include a pregnancy test, medical history, physical
exam, blood pressure, height and weight measurements, review of medications,
hirsutism and acne score,dietary and exercise counseling, and an exercise
test. Blood work will be done to determine sex hormone levels and other
hormones in the body at the initial visit, 12 month visit, and at the final
visit. DXA scanning and a
transvaginal/transabdominal ultrasound will be done at the baseline visit
and at the final visit. Lastly,
a bleeding diary will be collected every month for the 6-month period after
your childs initial visit.
*Recruitment temporarily closed*
Contact
Patricia Rawa at 1-800-585-9585 or 717-531-3692.
Study #9 Title: The
Effect of Combination Therapy with Lifestyle Intervention and Metformin in
Females with PCOS (Adult)
The purpose of this study is to offer you the
opportunity to take part in a study because you have the condition known as
Polycystic Ovary Syndrome (PCOS).
PCOS
is a condition that causes irregular periods, inability to get pregnant, and
excessive facial and body hair. The
United States Food and Drug Administration approve the drug used in this
study, Metformin, for the treatment of Type II diabetes.
However, it is commonly used in PCOS patients because of the
inability to properly process insulin, a hormone that controls blood sugar. This study is designed to compare the drug Metformin,
combined with exercise versus placebo (pill with no medication) combined
with exercise in females with PCOS.
The
study will examine the effect of these two different combinations on the
frequency of egg release from the ovaries, hyperandrogenemia (increased
levels of male hormones), and your sensitivity to insulin.
The study involves traveling to the Hershey Medical
Center every month after an initial visit over a 6-month period.
You will be assigned to one of two treatment groups.
One being Metformin combined with exercise, or placebo (pill with no
medication) combined with exercise.
The procedures that will take place at every monthly
visit include a pregnancy test, medical history, physical exam, blood
pressure, height and weight measurements, review of medications, hirsutism
and acne score,dietary and exercise counseling, and an exercise test. Blood
work will be done to determine sex hormone levels and other hormones in the
body at the initial visit, 12 month visit, and at the final visit.
DXA scanning and a transvaginal ultrasound will be done at the
baseline visit and at the final visit.
Lastly, daily urine samples and a daily urine collection and bleeding
diary will be collected every month for the 6-month period after your
initial visit. We will supply
you with all the materials for the urine collection.
*Recruitment temporarily closed*
Contact Patricia Rawa
at 1-800-585-9585 or 717-531-3692
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