Case #4

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If you have completed case D, this is a review. Completion of this case will not be counted toward your assignment.


Chief Complaint

You are the acute care doctor at the Family Practice Clinic, seeing Mrs. Brown for the first time. Mrs. Brown is a 67-year-old woman with a two-day history of swelling and pain in her right lower leg. The pain worsens with walking. Before evaluating Mrs. Brown, let’s review some important information about swelling of the legs.
  1. What is your differential diagnosis for unilateral swelling and pain in a lower extremity? Remember to keep your horizons broad. Also, now is a good time to review bilateral edema of the lower extremity. What is the differential diagnosis for bilateral edema of the lower extremity?
  2. As you ask Mrs. Brown for the “History of Present Illness,’ what key questions would help narrow the differential?

Medical History

Now let’s see Mrs. Brown. She remembers first noticing right calf pain when arising from bed yesterday morning. She noticed the right lower leg was swollen and red. She denies any traumatic event or recent strenuous activity. In fact, she just returned from her winter stay in Florida, and the long drive gave her legs a needed rest. The leg pain worsens with walking, especially pushing off with her toes. The pain is relieved with rest and elevation but her calf continues to hurt. She describes the pain to be most severe “inside her calf.” She has not had this leg swelling and pain previously and has never had leg edema. She denies fever or night sweats. She can’t recall any reason for her skin to be infected. She recalls no bites or scrapes to her calf area. Four months ago, Mrs. Brown had a breast mass removed that was found to be malignant. A local surgeon is following her and told her the nodes were cancer free and the tumor was completely removed.

 

  1. Do we need additional information before going on the physical exam? If so, what inquiries would you make?

Medical History con't

ROS: generally is negatives, and specifically the patient

- denies fatigue
- denies headache
- denies chest pain, palpitations
- no nausea, no vomiting

Past Medical History:

HTN: controlled
Osteoarthritis
Breast Cancer
Menopause at age 55

Surgical History:

Right breast masyectomy, 4 months ago, negative nodes
Total knee replacement 2 years ago

Meds:

Relafen 1000 mg po qday
Atenolol 50 mg qday

Allergies:

Penicillin (hives)

Social History:

Tobacco - 1 PPD x25 years
No alcohol use
Married, lives with husband. Retired school teacher with two daughters.

Family history:

No cancer
No peripheral vascular disease
No hypercoagulable conditions

Now that we have a complete history, let’s move on to the physical exam. Before you complete a thorough exam, we should make sure we are prepared to examine the lower extremities.

 

  1. What is important in a lower extremity examination? What is Homan’s sign?

Physical History

On physical exam, Mrs. Brown is mildly obese, alert, oriented and in NAD. She has a supple neck without lymphadenopathy or JVD. Lungs sounds are coarse throughout bilaterally. Her cardiac exam is normal - regular rate and rhythm, without murmurs. Abdominal exam is benign with normoactive bowel sounds, nontender, and no organomegaly.

On inspection, the right lower extremity (RLE) appears edematous and mildly erythematous distal to the knee compared to the left. The right calf is 24 cm and the left is 20 cm. There is no skin breakdown appreciated. On palpation, the right calf is warmer and firmer than the left, and the edema is nonpitting. Superficial palpation of the right calf is nontender. There is moderate tenderness to deep palpation over the calf and popliteal vein. Femoral, popliteal, posterior tibialis, and dorsalis pedis pulses are all 2+ and equal bilaterally. Homan’s sign is not present. Sensation is intact bilaterally.

 

  1. What most important information has been left out of the exam?
  2. What is your most likely diagnosis at this time?

Diagnostic Work-up

Before we move on to the laboratory and diagnostic studies, let’s learn more about DVT.

 

  1. What are the signs and symptoms of DVT?
  2. What are the clinical risk factors for deep venous thrombosis? Hint: What is Virchow’s Triad? Name five clinical risk factors of Mrs. Brown.
  3. Where do most venous thrombi arise?
  4.  What is the Wells Clinical Prediction Rule for DVT?
  5.  What is the next appropriate management step for Mrs. Brown?
  6. What diagnostic studies are available for DVT and which study is indicated for Mrs. Brown?
Mrs. Brown is sent to the nearby hospital for a diagnostic duplex ultrasound of the lower extremities.

While waiting in the Emergency Department waiting room, she develops sudden chest pain and shortness of breath. She is immediately taken to a room where hand-carried records from her family physician are quickly reviewed while the nurse takes her vital signs: BP 150/96 RR 21 Pulse 99.

  1. What serious complication of DVT has Mrs. Brown developed?
  2. What are the symptoms of PE?
  3. What are the clinical findings with PE?
  4. What is the pathophysiology of PE?
  5. What tests should be ordered immediately with suspected PE?
Mrs. Brown’s lab results reveal a normal CBC, lytes, PT/PTT, and cardiac profile. However, she has an elevated d-dimer - 4026.

Her CXR and EKG are as follows:

CXR - Without active disease. No definite infiltrate. Possible left atelectasis.

EKG - Normal Sinus Rhythm.

  1. What diagnostic studies are available to assist in confirming or ruling out a PE?
As Mrs. Brown’s lab studies are non-specific and the suspicion for PE is high, she is sent to radiology for a Spiral Chest CT.

The Chest CT demonstrates multiple pulmonary emboli bilaterally. Small pleural effusions and atelectasis are also noted.

Given her initial presentation, she is now sent for a duplex ultrasound of the lower extremities to determine if a DVT was the source of her PE. The ultrasound is positive for a DVT in her right lower extremity. Mrs. Brown has a calf vein thrombi extending to the popliteal veins. No further studies are needed in this case, but for your benefit, two venogram studies follow exhibiting obvious calf vein clots. Notice the opaque blood in veins ending in lucent areas. These lucent areas are clot. The key to finding clots is to look for “railroad tracks,” representing thin streaks of blood along the walls of veins. The blood is attempting to squeeze by the clot.

Unfortunately for Mrs. Brown she has a PE and DVT. The good news is that these conditions can be effectively treated if diagnosed and acted upon promptly.
 

  1. What is the Wells Clinical Prediction Rule for PE?
  2. How is the Wells criteria used in risk stratification and assessing likelihood of PE?
  3. What is the standard treatment protocol for a confirmed DVT or PE?
  4. What other treatment options are available for complicated or recurrent PEs?
  5. How long should a patient continue anticoagulation therapy?
  6. When Mrs. Brown leaves the hospital in approximately 5-7 days, what follow-up is necessary?
  7.  Mrs. Brown had known risk factors for DVT, including immobility, smoking, and malignancy. When a patient develops DVT or PE without any clear predisposing factors, what further studies should be sent?

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