Case #30

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Chief Complaint

Mrs. Joan Smith is a patient who is new to the office where you are working for your Family Medicine Clerkship. Your preceptor says that it would be a huge help if you could go in first and find out why Mrs. Smith is here and do a basic History and Physical.

Before entering the examination room, you look over Mrs. Smith’s new chart:
Age: 60 y.o.
CC: Shortness of breath
Vital signs: T = 36.8 oC, P = 80 bpm, R = 20 per min, BP = 138/75

  1. Before entering the room, you think about Mrs. Smith’s chief complaint: Shortness of breath.  Develop a general differential diagnosis for shortness of breath. (aka. Dyspnea)
You enter the examination room and see Mrs. Smith sitting in a chair reading one of the office magazines. You introduce yourself and then ask her, “What brings you in to the office today?” Mrs. Smith responds, “Well, I’ve been having a lot of shortness of breath recently. My daughter is getting concerned and said that I should go see a Doctor about it.”
  1. You have already developed a broad differential diagnosis for Mrs. Smith’s reported shortness of breath. What questions might you ask her to help you narrow down the differential?

Medical History

Mrs. Smith answers all of your questions for you. She reports that she cannot tell you exactly when her shortness of breath began, but she does know that five years ago she did not have any problems with shortness of breath, unless she walked a long distance (>15 minutes of walking). She reports that now she has difficulty when she walks to the corner grocery store, which is one block from her house, but denies any dyspnea at rest. She does report, however, that she has had a chronic cough and that occasionally she is able to cough up a colorless sputum in the morning. She denies any episodes of orthopnea or paroxysmal nocturnal dyspnea, as well as any edema, fever, chills, or night sweats.

When you questions her about her past medical history, she reports that she is currently a secretary at the local community college and has only ever worked as a housewife or a secretary. She reports that she used to smoke. When you further question her, you find out that she began smoking when she was around 15 years old and smoked ~1 ½ packs per day until she was 45 years old, at which point she stopped smoking and has not smoked since then. She denies ever having any allergies. She currently takes one aspirin a day because she heard that “…it is supposed to help my heart.” She reports that she is otherwise generally healthy and has no conditions for which she sees doctors or for which she takes medications.

  1.  In what ways, if any, has this new information changed your differential diagnosis?
  2. What are you going to look for on physical exam related to you differential?

Assessment

 

During your exam you find:

  • Normal head and neck exam
  • Lungs are clear to auscultation except for an occasional wheeze diffusely throughout. The expiratory phase is slightly prolonged and there is tachypnea (20 breaths per minute). There is no evidence of use of accessory muscles.
  • Cardiovascular exam is normal
  • Abdominal exam is normal
  • No edema, cyanosis, or clubbing of extremities
  • Normal neurologic exam
  1. What initial testing would you like to have for this patient?

Test Results

You discuss your ideas and plans for Mrs. Smith with your preceptor and your preceptor agrees with you. You schedule a follow-up appointment for Mrs. Smith in 1 week and arrange for her to get a CBC, EKG, and chest X-ray (CXR) in the attempt to further elucidate the etiology of her dyspnea (although you think you already have a good idea of what the problem is!)

Three days later your preceptor comes up to you and says that they have received the films from Mrs. Smith’s CXR, however the report seems to have gone missing. Your preceptor asks you to look at the CXR and give your interpretation.

 

 

 

 

 

 

Courtesy of Dr. David Hartman, The Pennsylvania State University, Department of Radiology. (Note: the vertical line in the right lung is artifact.)

  1. What is your interpretation of the AP chest X-ray?

Test Results

 

Mrs. Smith’s EKG and CBC are normal. You and your preceptor discuss Mrs. Smith’s clinical, physical, and radiologic findings. You both agree that there is significant suspicion that Mrs. Smith has COPD.

Mrs. Smith returns to the office for her scheduled follow-up appointment. She reports that she continues to have dyspnea and occasional cough.

  1. Mrs. Smith asks you: “So what is the problem?” How are you going to explain COPD to Mrs. Smith?
Mrs. Smith thanks you for taking time to explain COPD to her, however she wants to know what the next step is going to be.

 

  1. What is the next step in the diagnosis of Mrs. Smith’s COPD?
 

You send Mrs. Smith for spirometry and tell her to return for a follow-up visit in one week, at which point you will discuss the results of her pulmonary function testing with her and develop a specific management plan.

It is one week later and you are about to see Mrs. Smith at her follow-up appointment. Before going in to see her, you look at her spirometry results.
 

  1.  Interpret the results of Mrs. Smith’s PFT and explain how they support or refute your diagnosis of COPD.
  2. How would you stage the severity of Mrs. Smith’s COPD?
  3. Why do you think Mrs. Smith is experiencing dyspnea now and not five years ago?
  4. Now that you have a complete picture of Mrs. Smith’s disease, what pharmacological therapeutic options should you consider in treating Mrs. Smith’s COPD when it is stable (i.e. not an acute exacerbation)?
  5. What are other potential (nonpharmacologic) therapeutic options might you consider in the treatment of COPD?

 

You go in to see Mrs. Smith. When you walk in to the examination room Mrs. Smith introduces you to her daughter, Suzie, who has come to the appointment with her mother. You explain to Mrs. Smith the results from her spirometry evaluation and you ask her if she has any questions. She says that she has been reading on the Internet that COPD usually occurs in people who have smoked cigarettes, but that there is a genetic form of COPD as well, and she wonders if this could be why she has COPD, especially since she not longer smokes.

  1. What “genetic disease” is Mrs. Smith talking about?

 

You explain to Mrs. Smith about 1-antitrypsin and indicate that, given her lack of family history, her age at presentation, and her history of smoking, it is unlikely that she has an 1-antitrypsin deficiency. Mrs. Smith is relieved, however she tells you that she also read that exposure to second-hand smoke puts you at increased risk of developing COPD, and Mrs. Smith says that she often smoked around Suzie.

  1. Discuss the relationship between cigarette smoking, second-hand smoke, and COPD. What is the relationship between smoking cessation and COPD mortality?
You decide to initially start Mrs. Smith on tiotropium bromide (Spiriva) DPI (dry-powder inhaler) 1 inhalation daily and albuterol sulfate MDI (metered-dose inhaler) 2 puffs as needed for acute symptoms up to every four hours. Mrs. Smith seems happy with her treatment plan. You send her home with a follow-up appointment scheduled in
2 months.

Your preceptor remarks that she was impressed with your management of Mrs. Smith and her newly-diagnosed COPD. Your preceptor comments that she is noticing more and more women being diagnosed with COPD and asks you if you wouldn’t mind doing a little research on the epidemiology of COPD.

 

  1. Discuss the epidemiology of COPD and why you think that there are more women being diagnosed now with COPD versus 20 years ago.
As you are talking about Mrs. Smith with your preceptor, another medical student joins the conversation and you begin talking with them about what you have learned about COPD. It has been awhile since they have studied COPD and they ask you if Mrs. Smith has chronic bronchitis or emphysema.

 

  1. What would you say to the other medical student about COPD versus emphysema versus chronic bronchitis?
Nine months later you are doing your Family Medicine AI and you see that Mrs. Smith is on your service! In morning report you hear that she was admitted for “COPD Exacerbation”.

 

  1. What does “COPD Exacerbation” mean? What is it typically related to?
You go to see Mrs. Smith while she is in the hospital. She is pleasantly surprised when she sees you. She reports that she was doing fine until this episode of exacerbation. She reports that her dyspnea is now near her baseline, but that just a few days ago she was have significant difficulty with even walking two or three steps.

 

  1.  What additional health maintenance issues should Mrs. Smith be aware of in the future to potentially help prevent further exacerbations?
  2. What is cor pulmonale and how is it related to COPD?
  3. What factors for any patient with COPD are going to indicate an increased risk of mortality?

Bonus Question: What are the gross pathologic changes expected in a COPD lung?

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