Scientific Director:
Shaobo Zhu, MD
Consultant:
J. Stanley Smith, MD
Manager:
Daniel
Beard, MS x4676
Coordinator:
Molly Pells x5794
Location: C7718B
The Penn State
Hershey
Cancer Institute (PSHCI) Tissue Bank offers investigators
within PSHCI and its affiliates a resource to enhance
research into cancer and other disease processes.
All Penn State University researchers can request
tissue from the Tissue Bank with an approved Institutional Review
Board protocol. Tissue, associated blood, buccal cell
swabs, and
epidemiological data are made available free of charge. Informed consent from
donors is obtained through the PSHCI Tissue Bank, thereby
freeing investigators from that process. The PSHCI Tissue
Bank collects a wide variety
of tumor tissue as well as
adjacent normal tissue from
surgical resections done at
the Hershey Medical Center. Additionally, select normal control tissue
is
available.
Expedited review is now in place and
one could obtain tissue within two weeks time after
applying,
if your study involves retrospective data mining, pathology
correlative or ancillary studies. If your study is
prospective involving humans, human tissue,
epidemiology, Quality of life, survivorship, genetics, etc
than a full Scientific Review will be necessary.
Patients are
presented with a consent form which asks them to donate
tissue, blood, and buccal cells. Tissue samples are collected fresh,
typically within 25 minutes of surgical resection and
classified by the Pathology Department. The samples are then
frozen in cryovials and stored at -80°C. Blood is
collected in K2EDTA (purple top) Vacutainers™, placed on ice
until centrifuged, and its components (plasma, buffy coat,
and red blood cells) are stored at -80°C. Buccal cell swabs are
taken and then transferred onto Whatman FTA
Indicating Blotting Cards for future DNA processing. Each
tissue dispensed is accompanied by a final pathological
diagnosis, the donor's age, and gender. A pathology report
and tumor registry data may also be available. Upon special
request and review, a biostatistician is available to
compile donor questionnaires into epidemiological data for
statistical study.
As of November 03, 2009, the PSHCI
Tissue Bank has released
2,171 samples to 43 researchers here at Penn
State Hershey and University Park Campus for various research projects.
Several publications have resulted from these research
projects.**
Requests for biological specimens or questionnaire data
should follow the
Instuctions for Tissue Requests.
If requesting fresh frozen tissue or other information
please fill in the
PSHCI Tissue Request Form.
If you need fixed tissue the
Pathology Tissue Request Form
must also be
filled in and sent to Dan Beard HO72 or faxed to
717-531-0704.
Please keep in mind that any
tissue released is generally
all the tissue that we have
for that patient.
So use that tissue
sparingly.
|
We at the
Penn State
Hershey
Cancer
Institute
Tissue Bank
are
committed to
maintaining
the highest
standards in
the services
we offer
while
preserving
our donors’
information
in the
strictest
confidence.
q No
Patient
identifiers
will be
supplied.
q A
copy of the
protocol,
including
research
methods,
must be
supplied
with the
PSHCI
Tissue
Request Form.
q Requests
will be
reviewed by
the
Scientific
Review
Committee (SRC) of
the
PSHCI.
q The
SRC
will request
any
preliminary
data, which
confirms
that
research
methods have
been
successful
in pilot
studies.
q We
ask that
investigators
acknowledge
PSHCI
Tissue Bank
in all
publications
resulting
from the use
of those
tissues. |
|
|
|
** 1. Goldenberg,D.,I.S.Zagon,F.Fedok,H.Crist,and P.J.
McLaughlin. 2008 The presence of the opioid
growth factor(OGF)-OGF receptor(OGFr) axis in human non-medullsry
thyroid cancer. Thyroid, In press.
2. Bayerl, M.G., Abou-Elella,A.A.,
Bruggerman, R.D.,Conroy,E,J.,Hengst,J.A.,King,T.S.,Jimenez,M.,Claxton,D.F.
and Yun,J.K. Spingosine Kinase 1 Protein and mRNA are
Overexpressed in Non-Hodgkin Lymphomas and are Attractive
Targets for Novel Pharmacological Interventions.
Leukemia and Lymphoma. 2008. In press
3. Leah Kline,
Thomas Olson, Norman Lee, Rosalyn Irby. 2007
Prostate Apoptosis Response-4 Increases Apoptosis in
Response to 5-fluorouracil in Colon Cancer Cells and Reduces
Tumor Burden. Abstract.
4. IL13-Targeted Liposomes for
the Systemic Treatment of Peripheral Nerve Sheath Tumors----AANS
Abstract
5. Targeted liposomes in the
management of peripheral nerve sheath tumors----PNS Abstract
