Shared Facilities Research
Organic
Synthesis Core
Director: Dhimant Desai, Ph.D.
The
mission of the Organic Synthesis Core (OSC) is to provide the
Penn State Community with organic molecules and their
metabolites for biological studies as well as biomarkers,
standards and potential chemopreventive and chemotherapeutic
agents for the purpose of cancer prevention, detection and
treatment. A wide range of organic compounds not commercially
available or not available in large volume quantities will be
made available to investigators at a reduced cost. The facility
is overseen by Dr. Dhimant Desai and is presently located within
the Penn State Cancer Institute occupying a total space
requirement of 2050 sq.ft. At present, 1700 sq.ft is designated
for the sythesis of intermediates, carcinogens and
chemopreventive agents with the remaining 350 sq.ft for the
synthesis of radiolabeled compounds. The facility is also
equipped with several high-pressure liquid chromatographs (HPLC),
including one instrument with a beta-flow-one radioactivity
detector and a medium-pressure liquid chromatograph.
Compounds
Available for Synthesis:
-
Non-radiolabel and radioisotope-labeled Polynuclear aromatic
hydrocarbons (PAHs)
-
Tobacco-specific nitrosamines (TSNA)
-
Environmental and nutritional carcinogens
-
Metabolites
-
DNA adducts
-
Chemopreventive agents
-
Chemotherapeutic agents
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