Keith C. Cheng, M.D., Ph.D.
Professor and Chief, Division of Experimental Pathology
Professor of Pathology, Biochemistry and Molecular Biology,
and Pharmacology
Co-Director of the Penn State IBIOS Bioinformatics and
Genomics graduate program (with John Carlson)
Director, Zebrafish Functional Genomics and Imaging Core
|
 |
Office: Room C7866A
Core Lab: Room C7804
Telephone:
Office (717) 531-5635
Lab (717) 531-4704
Fax: (717) 531-5634
Email: kcheng76@gmail.com
Areas of interest:
Cancer
genetics, genomic instability, cell differentiation, genetics of human
pigmentation, web-based zebrafish atlas, image informatics, SNP database
analysis |
The Cheng lab is interested
in fundamental genetic and molecular mechanisms that cause cancer, basic
mechanisms underlying the relationship between human skin pigmentation and
cancer, and contributing to web-based infrastructures for science, education,
and public service. Our laboratory pioneered genetic screens in
zebrafish to
find new genes related to cancer. Our screens targeted two processes affected
in cancer: mutation and cell differentiation. We are producing an on-line,
high-resolution, full-lifespan atlas of the zebrafish that will be integrated
with other anatomical web sites of zebrafish, other model organisms, and other
disciplines. Collaboratively, we are developing 2D and 3D image informatics
tools for systems biology and medicine, and new methods for X-ray based high
resolution 3D imaging at cellular and subcellular resolutions. In 2005, we
discovered that the putative cation exchanger slc24a5 played a key role
in the evolution of light skin in Europeans and modulates vertebrate
pigmentation by its effect on melanosome morphogenesis. We are trying to
understand why people of East Asian ancestry are not as susceptible to skin
cancer as those of European ancestry, by exploring both the molecular mechanisms
of melanosome morphogenesis and the genetics underlying the light skin of East
Asians/Amerindians.
Answers to the basic question of how and why gene function is lost in somatic
tissues will contribute to our understanding of evolution and will help us to
understand how and why cancer cells tend to accumulate mutations. Those
mutations play a key role in the evolution of killer cancer cells from the
originally normal ones of cancer victims, and also the evolution of resistant
cancer cells after treatment. The tendency to mutate one's DNA can be called
genetic instability or genomic instability, and the phenotype of elevated
mutation rate is called mutator phenotype. In order to discover new
vertebrate genes that control mutation, we have used the zebrafish (Danio
rerio) to generate mutants that show elevated rates of somatic (body cell)
mutation. In this screen, we scored for increased somatic loss of
heterozygosity at a marker locus, golden. We expect genetic instability
to be caused by deficiencies in any of a number of functions, including
chromosome segregation, recombination, and DNA repair. We are studying the
characteristics of mutants, including the ability of the mutations to
significantly increase cancer susceptibility, and are engaged in the positional
cloning of these mutations. Insights gained from these studies will increase
our understanding of the molecular forces that drive evolution and may suggest
new ways to fight cancer. Since these genomic instability ("gin")
mutants tend to develop cancer, they represent an animal model for human genetic
syndromes that predispose to cancer, and may promote the detection of
environmental mutagens. This novel approach to the study of genetic instability
was sponsored originally by the Jake Gittlen Memorial Golf Tournament, American
Cancer Society, and the National Science Foundation.
We are also seeking to increase understanding of cellular
differentiation by studying mutants defective in cellular differentiation (dif).
These mutants are expected to be affected in any of a variety of functions that
may affect cell differentiation, cell cycle regulation, or cell communication (Mohideen
et al. 2003). Since these and other experiments require knowledge of the
normal gross and microscopic anatomy of the zebrafish, we are now generating a
web-based histology and 3D anatomic atlas, currently being executed in
collaboration with physicists at University of Chicago and Argonne National
Laboratory. This will be the first full life-span atlas of this type (see
zfatlas.psu.edu), which will provide a scaffold for gene expression and
morphological morphological phenotypic data generated in our laboratory and
globally. In recognition of important work being done on specific zebrafish
organ systems around the world, we welcome contributions to this effort. We
will use scientifically and educationally useful comparisons between stages and
organisms. Our goal is to provide a model system atlas with state-of-the-art
quality and the most advanced and useful links to related information.
Individuals will be able to use images from this resource, as long as
permissions are requested and approved by email, and appropriate citations
made. Instructions for acknowledgement of the origin of those images will be
provided along with permissions. Support for this project has been provided to
date by resources of the Jake Gittlen Cancer Research Foundation, and from the
National Center for Research Resources at NIH. The results of this work will be
integrated with the rich bioinformatics of the community zebrafish site, ZFIN
(established by Monte Westerfield and colleagues at the University of Oregon).
Plans are underway to expand the project to include comparisons with genetic,
reverse genetic, and disease abnormalities, other types of imaging,
cross-disciplinary development of new imaging technologies in collaboration with
engineers and computer scientists, integration with the web sites of other model
systems and disciplines.
We have actively encouraged other laboratories to use the
power of zebrafish functional genomics to study the functions of genes in the
context of the whole organism, and in development. We have developed the idea
that zebrafish functional genomics is a powerful tool for the dissection of the
functions of each of the possible combinations of subunit isoforms of multimeric
proteins. A detailed discussion of this functional genomics approach, being
pursued in collaboration with Drs. Robert Levenson (Na/K ATPase; Department of
Pharmacology, Penn State College of Medicine) and Janet Robishaw (heterotrimeric
G proteins, Weis Center for Research, Danville, PA) has been recently reviewed
(See Cheng, Levenson and Robishaw, 2003, below). We have also participated in
Glen Gerhard's pioneering work to define the lifespan of the zebrafish, to set
the stage for its use in the study of aging (see publications below with
Gerhard, of the Weis Center for Research in Danville).
We are exploring the idea of Systems Morphogenetics, which
will yield high-throughput phenotypic profiling as a tool to understand biology
and disease. This work, which is currently focused on creating X-ray based
micron-scale computed tomographic 3D imaging tools and analysis for whole-animal
phenotyping for the zebrafish phenome project, requires a highly collaborative
environment that applies cutting edge technologies from computer science,
engineering, materials science, bioinformatics, and genetics to the placing of
each of these genes in the spatial, temporal, and physiological context of the
whole organism. We are building of a team of partners from a broad range of
disciplines to create a complete digital map of zebrafish anatomy, microanatomy,
and gene expression, in order to create a bioinformatics focused on biological
function.
Current Personnel:
-
Brian
Canada,
canada@psu.edu, IBIOS Bioinformatics and
Genomics PhD candidate
-
Jean Copper,
jec13@psu.edu,
Lab Manager; Atlas Coordinator
-
Darin Clark,
dpclark6@gmail.com, Post-baccalaureate Research
Intern
-
Sans Emmert, Ph.D., sans.emmert@gmail.com,
positional cloning of zebrafish genomic instability genes gin10 and gin12.
-
Peggy Hubley,
pjh11@psu.edu, Zebrafish Facility Manager
-
Steven Peckins,
sep16@psu.edu,
Webmaster, Zebrafish Atlas
-
Zurab
Tsetskhladze,
zut3@psu.edu,
Post doc, Molecular,
morphogenetic and genetic mechanisms of melanosome morphogenesis
Fish Room Workers:
-
Animal Caretaker C:
Gail Broda
Alyssa
Broda
-
Research Support
Technician: Elizabeth Wilson, epw1@psu.edu
Current Collaborators:
-
Victor
Canfield, Ph.D., Assistant Professor, Dept Pharmacology; co-PI, melanosome
morphogenesis project, Functional Genomics, Bioinformatics, Zebrafish Atlas
Project.
-
Francesco
DeCarlo, Ph.D., Beamline physicist, Advanced Photon Laboratory, Argonne
National Laboratory. MicroCT imaging of zebrafish.
-
Stephen Ekker,
Ph.D., Professor of Biochemistry and Molecular Biology, Mayo Clinic,
Rochester, MN. Insertional mutagenesis tools for the finding of genomic
instability genes.
-
Patrick La
Riviere, Ph.D., Assistant Professor, Department of Radiology, University of
Chicago. MicroCT analysis of biological samples in the micron length scale.
(Link his name to: http://www.radiology.uchicago.edu/index.php?q=patrick-la-riviere-phd/patrick-la-riviere-phd)
-
Yanxi Liu,
Ph.D., Penn State University Department of Computer Science and
Engineering, Application of Symmetry Group Theory to Systems
Morphogenetics.
-
Wayne,
McLaughlin, Ph.D., wayne.mclaughlin@uwimona.edu.jm. University of West
Indies, Mona, Jamaica. Mapping of East Asian pigment genes.
-
Stephen
Oppernheimer, M.D., Oxford University. Mapping East Asian skin color genes.
-
James Wang,
Ph.D., Penn State University School of Information Sciences and Technology;
Image Analysis applications to Systems Morphogenetics.
-
Xianghui Xiao, Ph.D., Beamline physicist, Advanced Photon
Laboratory, Argonne National Laboratory. MicroCT imaging of zebrafish.
Training Opportunities:
Our laboratory pursues independent and collaborative projects utilizing
model system approaches to human disease, including Mendelian and population
genetics, genomics, molecular and cell biology. Our interests include
high-throughput phenotypic profiling for systems biology, cancer genetics,
genetic markers of human migration, the molecular genetics of human
pigmentation, the primary genetic determinants of genomic instability and
abnormal differentiation in cancer, and development of image recognition
tools for model systems and pathology. We are exploring second generation
screens for genomic instability mutants in zebrafish, and building
interfaces between model system and human atlases.
Currently, one postdoctoral
opportunity is available for an applicant with a strong background in
genetics and publications in English-language journals. Submission of one
or more fellowship applications will be required (international, federal,
foundation, or local) prior to arrival. For consideration, applicants
should send a statement of life goals, scientific interests, and pdf's of
publications. Applications should be emailed to
kcheng76@gmail.com, with copies to
Jean Copper (jec13@psu.edu) for
coordination.
Graduate candidates should apply
through one of the following Penn State programs: MD/PhD
program of the College of Medicine, Molecular Medicine option of the
Integrative Biosciences Graduate Program in the Life
Sciences Consortium, Cell and
Molecular Biology, Biochemistry
& Molecular Biology, and Intercollege
Graduate Degree Program in Genetics.
Links: ZFIN
at Univ. of Oregon
Education and Certification:
B.A., Harvard University, 1976
M.D., New York University School of Medicine, 1980
Ph.D., University of Washington and Fred Hutchinson Cancer Research Center, 1986
Residency: Brigham & Women's Hospital, 1980-81; University of Washington, 1981-82,
1986-87
Graduate School: University of Washington and Fred Hutchinson Cancer Research
Center, 1982-86
Postdoc: University of Washington, 1987-1992.
| For the cover article written for the lay public about genetics,
genomics and the work of the Cheng lab, see http://www.rps.psu.edu/0109/model.html.
The article is adapted from Keith's concluding talk for the 2001
Penn State Frontiers of Science Lecture Series "Decoding Life's
Instruction Book: Genetics and Genomics." The title of his talk,
"A Model for Humans," is also an article in Research Penn
State, by Teresa Rafacz, September 2001, Volume 22, Issue 3. |
Publications (selected):
-
Cheng KC, Smith GR. Recombinational hotspot activity of Chi-like sequences. J
Mol Biol 180:371-377, 1984.
PMID: 6239928 [View
PDF]
-
Cheng KC, Smith GR. Cutting of Chi-like sequences by RecBCD enzyme of Escherichia
coli. J
Mol Biol 194:747-750,
1987.
PMID: 2958631 [View
PDF]
-
Cheng KC, Smith GR. Distribution of Chi-stimulated recombinational exchanges and
heteroduplex endpoints in phage lambda. Genetics 123:5-17, 1989.
PMID: 2530132
[View
PDF]
-
Cheng KC, Dias M. Genomic Instability and Cancer: Cause and Effect (invited Keystone
Meeting review). Cancer Cells 3:188-192, 1991.
PMID: 1679993 [View
PDF]
-
Cheng KC, Preston BD, Cahill DS, Dosanjh MK, Singer B, Loeb LA. The vinyl chloride DNA derivative,
N2,3-ethenoguanine, causes G to A transitions in E. coli. Proc Natl
Acad Sci, USA. 88:9974-9978, 1991.
PMID: 1946466 [View
PDF]
-
Cheng KC, Cahill DS, Kasai, Nishimura S, Loeb LA. 8-Hydroxyguanine, an abundant form of
oxidative DNA damage, causes G - T and A - C substitutions. J Biol Chem 267:166-172,
1992.
PMID: 1730583
[View
PDF]
-
Cheng KC, Loeb LA. Genomic Instability and tumor progression: mechanistic
considerations. Advances in Cancer Research 60:121-156, 1993.
PMID: 8417498
[View PDF]
-
Kauffman EJ, Gestl EE, Kim DJ, Walker C, Hite JM, Yan G, Rogan PK, Johnson SL, Cheng KC.
Microsatellite-centromere mapping in the zebrafish (Danio rerio). Genomics 30:337-341,
1995.
PMID: 8586435 [View
PDF]
-
Ham P, Cheng K. Construction of zebrafish spawning cages. The
Zebrafish Science Monitor, pp. 5-8, December 18, 1995. [View
PDF]
-
Hite JM, Eckert KE, Kauffman EJ, Cheng KC. Factors affecting fidelity of DNA synthesis
during PCR amplification of d(CA)n d(G-T)n microsatellite repeats. Nucleic Acids
Res 24:2429-2434,
1996.
PMID: 8710517 [View
PDF]
-
Cheng KC, Loeb LA. Genomic stability and instability: A working paradigm. In Current
Topics in Microbiology and Immunology, Chapter 2, M.B. Kastan (ed.), Springer-Verlag,
Berlin, pp. 5-18, 1997.
PMID: 8979437 [View
PDF]
-
Gestl EE, Kauffman EJ, Moore JL, Cheng KC. New conditions for generation of gynogenetic
half-tetrad embryos in the zebrafish, Danio rerio. J Heredity 88:76-79,
1997. [View
PDF]
-
Cheng KC, Moore JL. Genetic dissection of vertebrate processes in zebrafish: A
comparison of uniparental and two-generation screens. Biochemistry and Cell Biology
75:525-533, 1997.
PMID: 9551177 [View
PDF]
-
Cheng KC. A day well-spent for science: a first experience with Scientific
Congressional Advocacy. The ASCB Newsletter 21(3), April 1998.
http://www.ascb.org/news/vol21no3/brief2.htm
-
Cheng K. You can't win the Indy 500 in a Yugo: Help NSF funding: An
op-ed. In HMS Beagle: The BioMedNet Magazine, Issue 28, Apr. 17, 1998.
-
Tsao-Wu GS, Weber CH, Budgeon LR, Cheng KC. Agarose embedded tissue arrays for
histologic and genetic analysis. Biotechniques 25:614-618,
1998.
PMID: 9793642
[View
PDF]
-
Tsao-Wu GS, Weber CH, Budgeon LR, Cheng KC. Agarose embedded tissue arrays for
histologic and genetic analysis. In Expression Genetics:
High-Throughput Methods, Chapter 4, M. McClelland and A. Pardee (eds.), Eaton
Publishing, pp. 31-36, 1999.
[View
PDF]
-
Cheng KC, Beckwith L, Wang X. Update to: Agarose embedded tissue arrays for
histological
and genetic analysis. In Expression Genetics: High-Throughput Methods,
M. McClelland and A. Pardee (eds.), Eaton Publishing, p. 37, 1999.
[View
PDF]
-
Beckwith LG, Moore JL, Tsao-Wu GS, Harshbarger JC, Cheng KC. Ethylnitrosourea induces
neoplasms in zebrafish (Danio rerio). Lab Invest
80:379-385, 2000 (cover article).
PMID: 11956074
[View
PDF]
-
Mohideen M-APK, Moore JL, Cheng KC. Centromere-linked microsatellite markers for linkage
groups 3, 4, 6, 7, 13 and 20 of zebrafish (Danio rerio). Genomics
67:102-106, 2000.
PMID: 10945477
[View
PDF]
-
Rajarao
SJR, Canfield VA, Mohideen M-APK, Postlethwait JH, Cheng KC, Levenson R.
The
repertoire of Na,K-ATPase a and b subunit genes expressed in the
zebrafish, Danio rerio. Genome
Research 11:1211-1220, 2001.
PMID: 11435403
[View
PDF]
-
Moore
JL, Aros M, Steudel KG, Cheng KC.
Fixation and decalcification of adult zebrafish for histological,
immunocytochemical, and genotypic analysis. Biotechniques
32:296-298, 2002.
PMID: 11848405
[View
PDF]
-
Gerhard
GS, Kaufmann EJ, Wang X, Stewart R, Moore JL, Kasales CJ, Cheng KC.
Life spans and senescent phenotypes in an outbred and an inbred strain
of zebrafish (Danio rerio). Exp. Gerontology
37:1055-1068, 2002.
PMID: 12213556 [View
PDF]
-
Gerhard GS, Cheng KC. A call to fins! Zebrafish as a
gerontological model. Aging Cell 1:104-111, 2002. [View
PDF]
-
Mohideen
M-APK, Beckwith LG,
Tsao-Wu
GS, Moore JL, Wong ACC, Chinoy MR, Cheng KC. Histology-based
screen for zebrafish mutants with abnormal cell differentiation. Developmental Dynamics
228:414-423,
2003. PMID: 14579380 [View
PDF]
-
Cheng
KC, Levenson RL, Robishaw JD. Functional genomic dissection of
multimeric protein families in zebrafish.
Developmental Dynamics 228:555-567, 2003.
PMID: 14579392
[View PDF]
-
Moore
JL, Gestl EE, Cheng KC. Mosaic
eyes, genomic instability mutants, and cancer susceptibility.
Meth Cell Biol 76:555-568, 2004. PMID: 15602892
-
Gerhard
GS, Malek RL, Keller E, Murtha J, Cheng KC.
Zebrafish, Killifish, neither fish, both fish?
J Gerontol 59:B873-B875, 2004. PMID: 15472148 [View
PDF]
-
Cheng KC. A life-span atlas for the zebrafish
(announcement). Zebrafish 1:69, 2004. [View
PDF]
-
Cheng KC. Zebrafish experts speak (editorial). Zebrafish
1:85-103, 2004. [View
PDF]
-
Ostrander GK, Cheng KC, Wolf JC, Wolfe MJ. Shark cartilage,
cancer and the growing threat of pseudoscience. Cancer Res 64:8485-8491,
2004. PMID: 15574750 [View
PDF]
-
Cheng KC. As I See It: Use science to support global policy.
Harrisburg
Patriot-News, December 12, 2004, F1, 6.
[View
PDF]
-
Duffy KT, McAleer MF, Davidson WR, Kari L, Kari C, Liu C-G, Farber
SA, Cheng KC, Mest JR, Wickstrom E, Dicker AP, Rodeck U. Coordinate
control of cell cycle regulatory genes in zebrafish development tested
by cyclin D1 knockdown with morpholino phosporodiamidates and
hydroxyprolyl-phosophono peptide nucleic acids. Nucleic Acids
Res 33:4914-4921, 2005. PMID: 16284195
[View PDF]
-
Croushore JA, Blasiole B, Riddle RC, Thisse C, Thisse B, Canfield VA,
Robertson GP, Cheng KC, Levenson R. ptena and ptenb genes play distinct
roles in zebrafish embryogenesis. Developmental Dynamics
234:911-921, 2005. PMID: 16193492 [
[View PDF]
-
Lamason RL, Mohideen
M-AP, Mest JR, Wong AC, Norton HL, Aros MC, Juurynec MJ, Mao X,
Humphreville VR, Humbert JE, Sinha S, Moore JL, Jagadeeswaran P, Ning G,
Makalowska I, Zhao W, McKeigue PM, O'Donnell D, Kittles R, Parra EJ,
Mangini NJ, Grunwald DJ, Shriver MD, Canfield VA, Cheng KC. SLC24A5
affects pigmentation in zebrafish and man. Science
310:1782-1786, 2005. (cover article) PMID: 16357253 [due to the large file size of the
supplement and cover, we offer three versions:
SciencePaperNoSuppl.pdf
(the paper as presented in the journal;
457kb),
SciencePaper&Suppl.pdf
(the paper in the journal, including the
supplementary data; 2857kb), and
Science16Dec2005cover.pdf (just the cover, in high resolution,
originally submitted with the caption, "Skin color is only gene deep";
5814kb)].
Science 16 December 2005 "News of the Week".
-
Zinnanti WJ, Lazovic J, Wolpert EB,
Antonetti DA, Smith MB, Connor JR, Woontner M, Goodman SI, Cheng KC.
A diet-induced mouse model for glutaric aciduria type I. Brain
129:899-910,
2006. PMID: 16446282
[View PDF]
-
Cheng KC. The golden mutation in
zebrafish. Commentary #1, February 2006 PASPCR web-site posting.
[View PDF]
-
Cheng KC.
Bach's Goldberg Variations: An artistic inspiration for art, science,
medicine, and life. Wild Onions 20:14-15, 2006.
[View PDF]
-
Blasiole B, Canfield VA,
Mohideen M-APK, Vollrath MA, Huss D, Dickman JD, Cheng KC, Fekete DM,
Levenson, RL. Separate Na,K-Atpase genes are required for otolith
formation and semicircular canal development in zebrafish. Dev Biol
294:148-160, 2006. PMID: 16566913
[View PDF]
-
Zinnanti
WJ, Lazovic J, Wolpert EB, Antonetti DA, Smith MB, Connor JR, Woontner
M, Goodman SI, Cheng KC. New insights for glutaric aciduria type I.
Brain 129:E55, 2006. PMID: 16870880
[View PDF]
-
Sabaliauskas NA, Foutz CA, Mest JR, Budgeon LR, Sidor A, Gershenson J,
Joshi S, Cheng KC. High-throughput zebrafish histology. Methods
39:246-254,
2006. PMID: 16870470
[View PDF]
-
Moore JL, Rush LM,
Breneman C, Mohideen M-AP, Cheng, KC. Zebrafish genomic instability
mutants and cancer susceptibility. Genetics 174:585-600,
2006 (October cover article), 2006. PMID: 16888336
[View PDF]
-
Cheng KC, Canfield VA.
The role of SLC24A5 in skin color. Invest Dermatol 16:836-838, 2006.
[View PDF]
-
Canada BA, Cheng KC,
Wang JZ. QCHARM: A Novel Computational and Scientific Visualization
Framework for Facilitating Discovery and Improving Diagnostic
Reliability in Medicine. Proceedings of the American Medical
Informatics Association Annual Symposium, pp. 870, Washington, D.C.,
November 2006.
[View PDF]
-
Chi A, Valencia JC, Hu
Z-Z, Watabe H, Yamaguchi H, Mangini NM, Huang H, Canfield VA, Cheng KC,
Yang OF, Abe R, Yamagishi S, Shabanowitz J, Hearing VJ, Wu C, Appella E,
Hunt DF. Proteomic and bioinformatic characterization of the biogenesis
and function of melanosomes. J Proteome Res 5:3135-3144, 2006.
PMID: 17081065
[View PDF]
-
Norton HL, Kittles RA,
Parra E, McKeigue P, Mao X, Cheng KC, Canfield VA, Bradley DG, McEvoy B, Shriver
MD. Genetic evidence for the convergent evolution of light skin in
Europeans and East Asians. Molecular Biol
Evol 24:710-722, 2007. PMID: 17182896
[View PDF]
-
Zinnanti WJ, Lazovic J,
Housman C, LaNoue K, O'Callaghan JP, Simpson I, Woontner M, Goodman SI,
Connor JR, Jacobs RE, Cheng KC. Mechanism of age-dependent
susceptibility and novel treatment strategy in glutaric acidemia type
I. J Clin Invest
117:3258-3270, 2007. PMID: 17932566
[View PDF]
-
Canada BA, Thomas GK,
Cheng KC*, Wang JZ.* Automated segmentation and classification of
zebrafish histology images for high-throughput phenotyping.
Proceedings of the Third IEEE-NIH Life Science Systems and Applications
Workshop, pp. 245-248, Washington, D.C., November 2007. (*equal
contributors)
ISBN number: 978-1-4244-1813-8
[View PDF]
-
Cheng KC. Demystifying Skin Color and "Race". In
R.E. Hall (ed.): Racism in the 21st Century, Chapter 1, pp.
3-23, Springer, 2008. [http://books.google.com/books?id=LSCf0j5lNeYC&printsec=frontcover&dq=editions:ISBN0387790977#PPA10,M1]
-
Canada BA, Thomas GK,
Cheng KC, Wang JZ, Liu Y. Towards Efficient Automated Characterization
of Irregular Histology Images via Transformation to Frieze-Like
Patterns. Proceedings of the ACM International Conference on Image
and Video Retrieval (CIVR 2008), pp. 581-590, Niagara Falls, Canada,
July 2008.
[View PDF]
-
Canada BA, Thomas GK,
Cheng KC, Wang JZ, Liu Y. Automatic Lattice Detection in Near-Regular
Histology Array Images. Proceedings of the IEEE International
Conference on Image Processing (ICIP), San Diego, California, IEEE,
October 2008.
[View PDF]
-
Cheng KC. Skin color in
fish and humans: Impacts on science and society. Zebrafish
5:237-242, 2008. PMID: 19133821 [View PDF]
-
Ekker SC, Parichy DM, Cheng KC. Research
implications of pigment biology in zebrafish.
Zebrafish
5:233-235, 2008. PMID: 19133820 [View PDF]
-
Spitsbergen JM, Blazer
VS, Bowser PR, Cheng KC, Cooper KR, Cooper TK, Frasca S Jr., Groman DB,
Harper CM, Law JM, Marty GD, Smolowitz RM, St. Leger J, Wolf DC, Wolf JC.
Finfish and aquatic invertebrate pathology resources for now and the
future. Comparative Biochemistry and Physiology, Part C
149:249–257, 2009. [For a copy
of the paper, please send a request to
sef13@psu.edu]
-
Zinnanti WJ, Lazovic J,
Griffin K, Skvorak KJ, Paul HS, Homanics GE, Bewley MC, Cheng KC, LaNoue
KF, Flanagan JM. Dual mechanism of brain injury and novel treatment
strategy in maple syrup urine disease. Brain 2009; doi:
10.1093/brain/awp024.
[For a copy
of the paper, please send a request to
sef13@psu.edu]
-
Cheng KC, Waldstein N. Unraveling
genetic code: Social, moral questions arise from DNA (Text submitted
as, "What does the human genome project mean to me") Review & Opinion
section, Harrisburg Patriot-News, Feb 15, 2009.
[View PDF]
-
Cheng KC. Zebrafish
experts speak (editorial). Zebrafish 5:9-24, 2008.
[View PDF]
 FREQUENTLY
ASKED
QUESTIONS
What is your goal in life?
Pigmentation Research:
What might your work in human pigmentation
contribute to human health?
What do you hope the pigment gene discovery
might contribute to society?
What have been the most common public
misconceptions about skin color?
Will it be at all possible to change a person’s
skin color from white to black or black to white in the near future? Or do you
think your discovery can allow people to have a choice in what skin tone they
have?
Does the work on SLC24A5 bring us closer to
a cure for vitiligo?
I heard that you met with the Race,
Ethnicity, and Genetics Working Group at the National Human Genome Research
Institute at NIH. What were your conclusions?
Tell us more about mutation and evolution.
Is there any direct evidence that SLC24A5
is related to intelligence?
Is there anything not talked about with regard
to the skin pigmentation work you would like to point out?
When
did you become interested in genomic instability?
When
did you decide to use zebrafish as a cancer model?
What
is your training philosophy?
What
is required of graduate students for graduation?
How
long will graduate school take?
What
is required for success in graduate school?
What
is expected of postdoctoral fellows?
How
and when did you think of your histology screen?
Explain
your interest in Functional Genomics.
When
did you become interested in cancer research?
How
is it that you came to Penn State?
Who
are you willing to hire, when?
I
heard you are a musician. Tell us about it.
What
is MUSIC for JAKE, and are you playing again?
Why
were you on the Board of Directors of WITF?
What
is the Kienle Series?
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