Experimental Pathology

Keith C. Cheng, M.D., Ph.D. Professor and Chief, Division of Experimental Pathology Professor of Pathology, Biochemistry and Molecular Biology, and Pharmacology   Co-Director of the Penn State IBIOS Bioinformatics and Genomics graduate program (with John Carlson) Director, Zebrafish Functional Genomics and Imaging Core
	Office:  Room C7866A Core Lab:  Room C7804 Telephone:    Office (717) 531-5635     Lab (717) 531-4704 Fax:  (717) 531-5634 Email:  kcheng76@gmail.com   Areas of interest: Cancer genetics, genomic instability, cell differentiation, genetics of human pigmentation, web-based zebrafish atlas, image informatics, SNP database analysis

The Cheng lab is interested in fundamental genetic and molecular mechanisms that cause cancer, basic mechanisms underlying the relationship between human skin pigmentation and cancer, and contributing to web-based infrastructures for science, education, and public service.  Our laboratory pioneered genetic screens in zebrafish to find new genes related to cancer.  Our screens targeted two processes affected in cancer: mutation and cell differentiation.  We are producing an on-line, high-resolution, full-lifespan atlas of the zebrafish that will be integrated with other anatomical web sites of zebrafish, other model organisms, and other disciplines.  Collaboratively, we are developing 2D and 3D image informatics tools for systems biology and medicine, and new methods for X-ray based  high resolution 3D imaging at cellular and subcellular resolutions.  In 2005, we discovered that the putative cation exchanger slc24a5 played a key role in the evolution of light skin in Europeans and modulates vertebrate pigmentation by its effect on melanosome morphogenesis. We are trying to understand why people of East Asian ancestry are not as susceptible to skin cancer as those of European ancestry, by exploring both the molecular mechanisms of melanosome morphogenesis and the genetics underlying the light skin of East Asians/Amerindians.

Answers to the basic question of how and why gene function is lost in somatic tissues will contribute to our understanding of evolution and will help us to understand how and why cancer cells tend to accumulate mutations. Those mutations play a key role in the evolution of killer cancer cells from the originally normal ones of cancer victims, and also the evolution of resistant cancer cells after treatment. The tendency to mutate one's DNA can be called genetic instability or genomic instability, and the phenotype of elevated mutation rate is called mutator phenotype. In order to discover new vertebrate genes that control mutation, we have used the zebrafish (Danio rerio) to generate mutants that show elevated rates of somatic (body cell) mutation.  In this screen, we scored for increased somatic loss of heterozygosity at a marker locus, golden. We expect genetic instability to be caused by deficiencies in any of a number of functions, including chromosome segregation, recombination, and DNA repair.  We are studying the characteristics of mutants, including the ability of the mutations to significantly increase cancer susceptibility, and are engaged in the positional cloning of these mutations.  Insights gained from these studies will increase our understanding of the molecular forces that drive evolution and may suggest new ways to fight cancer.  Since these genomic instability ("gin") mutants tend to develop cancer, they represent an animal model for human genetic syndromes that predispose to cancer, and may promote the detection of environmental mutagens. This novel approach to the study of genetic instability was sponsored originally by the Jake Gittlen Memorial Golf Tournament, American Cancer Society, and the National Science Foundation.

Zebrafish (www.zfin.org): The zebrafish is an inch-long tropical fish with rapidly-developing, transparent embryos and a powerful bag of genetic tricks developed by the late George Streisinger at the University of Oregon in the early 1970’s, when he was the only zebrafish geneticist. Of three scientists sharing the 1995 Nobel Prize in Biology for the generation of developmental mutants in Drosophila, one, Nusslein-Volhard, has now completed a large-scale mutant screen in zebrafish (see the special Zebrafish issue of Development, December 1996). Its genome is currently being sequenced at the Sanger Center (http://www.sanger.ac.uk/Projects/D_rerio/).  Such work has made the zebrafish a premier vertebrate genetic model system (used now by about 500 research laboratories worldwide).

We are also seeking to increase understanding of cellular differentiation by studying mutants defective in cellular differentiation (dif). These mutants are expected to be affected in any of a variety of functions that may affect cell differentiation, cell cycle regulation, or cell communication (Mohideen et al. 2003).   Since these and other experiments require knowledge of the normal gross and microscopic anatomy of the zebrafish, we are now generating a web-based histology and 3D anatomic atlas, being executed in collaboration with Dr. Stephen Moorman (Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical School; http://www2.umdnj.edu/~moormasj/Zebrafish-Anatomy-Project.html).  This will be the first full life-span atlas of this type (for status report, see zfatlas.psu.edu), into which we intend to use as a scaffold for other morphological data generated both in other lab and others.  In recognition of the wonderful work being done on specific zebrafish organ systems around the world, we welcome contributions to this effort.  We will use scientifically and educationally useful comparisons between stages and organisms to the best of our abilities.  Our goal is to provide a model system atlas with state-of-the-art quality and the most advanced and useful links to related information.  Individuals will be able to use images from this resource, as long as permissions are requested and approved by email, and appropriate citations made.  Instructions for acknowledgement of the origin of those images will be provided along with permissions.  Support for this project has been provided to date by resources of the Jake Gittlen Cancer Research Institute grant from the National Institutes of Health for an ongoing histology screen, and is now provided by a grant from the National Center for Research Resources at NIH.  The results of this work will be integrated into the rich bioinformatics of the community zebrafish site, zfin, established by Monte Westerfield and colleagues at the University of Oregon.  Plans are underway to expand the project to include comparisons with genetic, reverse genetic, and disease abnormalities, other types of imaging, cross-disciplinary development of new imaging technologies in collaboration with engineers and computer scientists, integration with the web sites of other model systems and disciplines, and use of Grid computing technologies. 

We have actively encouraged other laboratories to use the power of zebrafish functional genomics to study the functions of genes in the context of the whole organism, and in development.  We have developed the idea that zebrafish functional genomics is a powerful tool for the dissection of the functions of each of the possible combinations of subunit isoforms of multimeric proteins.  A detailed discussion of this functional genomics approach, being pursued in collaboration with Drs. Robert Levenson (Na/K ATPase; Department of Pharmacology, Penn State College of Medicine) and Janet Robishaw (heterotrimeric G proteins, Weis Center for Research, Danville, PA) has been recently reviewed (See Cheng, Levenson and Robishaw, 2003, below).  We have also participated in Glen Gerhard's pioneering work to define the lifespan of the zebrafish, to set the stage for its use in the study of aging (see publications below with Gerhard, of the Weis Center for Research in Danville).

We are exploring the idea of Systems Morphogenetics (manuscript in preparation), which provides an answer to the growing problem that the gene outputs of high-throughput genomics approaches, including microarray and proteomic approaches, require anatomical, developmental, and physiological context to suggest the next level of experimentation.  This work requires a highly collaborative environment that applies cutting edge technologies from computer science, engineering, materials science, bioinformatics, and genetics to the placing of each of these genes in the spatial, temporal, and physiological context of the whole organism.  The Penn State Systems Morphogenetics Group was founded to enable development of new research approaches for Penn State investigators, new government/Penn State and Drug company/Penn State partnerships, and to stimulate new ideas that arise from the bringing together of individuals from a broad range of disciplines.  A Systems Morphogenetics Symposium was held at the FASEB meeting in San Diego in April, 2005.

Current Personnel:   

• Mary Burns, mmb29@psu.edu, Post doc, Golden Project

• Brian Canada, canada@psu.edu, IBIOS Bioinformatics and Genomics PhD candidate

• Anthony Cheng, amcheng@gmail.com, Post-baccalaureate Research Intern - Labeling Manager, Zebrafish Atlas

• Jean Copper, jec13@psu.edu, Lab Manager; Atlas Coordinator

• Michael Gallagher, mdg17@psu.edu, Post-baccalaureate Research Intern

• Peggy Hubley, pjh11@psu.edu, Zebrafish Facility Manager

• Steven Peckins, sep16@psu.edu, Webmaster, Zebrafish Atlas

• Georgia Thomas, gkt104@psu.edu, Cell and Molecular Biology PhD candidate; Pleiotropy

• Zurab Tsetskhladze, zut3@psu.edu, Post doc, Golden Project

• Steve Wentzel, mrschmooshies@gmail.com, Graduate Student; Genomic instability, and cell differentiation screen

Fish Room Workers:

• Animal Caretaker C:  Gail Broda
                                 Alyssa Broda

• Research Support Technician:  Elizabeth Wilson, epw1@psu.edu

Current Collaborators:

• Victor Canfield, Ph.D., Assistant Professor, Dept Pharmacology; co-PI, melanosome morphogenesis project, Functional Genomics, Bioinformatics, Zebrafish Atlas Project.

• Stephen Ekker, Ph.D.  Professor of Biochemistry and Molecular Biology. Insertional mutagenesis tools for the finding of genomic instability genes.

• Yanxi Liu, Ph.D.,  Penn State University Department of Computer Science and Engineering,  Application of Symmetry Group Theory to Systems Morphogenetics.

• Wayne, McLaughlin, Ph.D., wayne.mclaughlin@uwimona.edu.jm. University of West Indies, Mona, Jamaica. Mapping of East Asian pigment genes.

• Stephen J. Moorman, Ph.D., Robert Wood Johnson Medical School, Piscataway, NJ; Co-PI, Zebrafish Atlas.3D reconstructions of zebrafish embryos from plastic sections.

• Stephen Oppernheimer, M.D., Oxford University. Mapping East Asian skin color genes.

• James Wang, Ph.D., Penn State University School of Information Sciences and Technology; Image Analysis applications to Systems Morphogenetics.

 

Training Opportunities:  Our laboratory pursues independent and collaborative projects utilizing model system approaches to human disease, including Mendelian and population genetics, genomics, molecular and cell biology.  Our interests include cancer genetics, genetic markers of human migration, the molecular genetics of human pigmentation, the primary genetic determinants of genomic instability and abnormal differentiation in cancer, and development of image recognition tools for model systems and pathology.  We are exploring second generation screens for genomic instability mutants in zebrafish, and building interfaces between model system and human atlases.

Currently, one postdoctoral opportunity is available for an applicant with a strong background in genetics and publications in English-language journals.  Submission of one or more fellowship applications will be required (international, federal, foundation, or local) prior to arrival.  For consideration, applicants should send a statement of life goals, scientific interests, and pdf's of publications.  Applications should be emailed to kcheng76@gmail.com, with copies to Jean Copper (jec13@psu.edu) for coordination.

Graduate candidates should apply through one of the following Penn State programs: MD/PhD program of the College of Medicine, Molecular Medicine option of the Integrative Biosciences Graduate Program in the Life Sciences Consortium, Cell and Molecular Biology, Biochemistry & Molecular Biology, and Intercollege Graduate Degree Program in Genetics.

Links:  ZFIN at Univ. of Oregon

Education and Certification:

B.A., Harvard University, 1976

M.D., New York University School of Medicine, 1980

Ph.D., University of Washington and Fred Hutchinson Cancer Research Center, 1986

Residency: Brigham & Women's Hospital, 1980-81; University of Washington, 1981-82, 1986-87

Graduate School:  University of Washington and Fred Hutchinson Cancer Research Center, 1982-86

Postdoc: University of Washington, 1987-1992.

Publications (selected):

• Cheng KC, Smith GR. Recombinational hotspot activity of Chi-like sequences. J Mol Biol 180:371-377, 1984.  PMID: 6239928  [View PDF]

• Cheng KC, Smith GR. Cutting of Chi-like sequences by RecBCD enzyme of Escherichia coli. J Mol Biol 194:747-750, 1987.  PMID: 2958631  [View PDF]

• Cheng KC, Smith GR. Distribution of Chi-stimulated recombinational exchanges and heteroduplex endpoints in phage lambda. Genetics 123:5-17, 1989.  PMID: 2530132  [View PDF]

• Cheng KC, Dias M. Genomic Instability and Cancer: Cause and Effect (invited Keystone Meeting review). Cancer Cells 3:188-192, 1991.  PMID: 1679993  [View PDF]

• Cheng KC, Preston BD, Cahill DS, Dosanjh MK, Singer B, Loeb LA. The vinyl chloride DNA derivative, N²,3-ethenoguanine, causes G to A transitions in E. coli. Proc Natl Acad Sci, USA. 88:9974-9978, 1991.  PMID: 1946466 [View PDF]

• Cheng KC, Cahill DS, Kasai, Nishimura S, Loeb LA. 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G - T and A - C substitutions. J Biol Chem 267:166-172, 1992.  PMID: 1730583  [View PDF]

• Cheng KC, Loeb LA. Genomic Instability and tumor progression: mechanistic considerations. Advances in Cancer Research 60:121-156, 1993.  PMID: 8417498  [View PDF]

• Kauffman EJ, Gestl EE, Kim DJ, Walker C, Hite JM, Yan G, Rogan PK, Johnson SL, Cheng KC. Microsatellite-centromere mapping in the zebrafish (Danio rerio). Genomics 30:337-341, 1995.  PMID: 8586435  [View PDF]

• Ham P, Cheng K.  Construction of zebrafish spawning cages.  The Zebrafish Science Monitor, pp. 5-8, December 18, 1995.  [View PDF]

• Hite JM, Eckert KE, Kauffman EJ, Cheng KC. Factors affecting fidelity of DNA synthesis during PCR amplification of d(CA)n d(G-T)n microsatellite repeats. Nucleic Acids Res 24:2429-2434, 1996.  PMID: 8710517 [View PDF]

• Cheng KC, Loeb LA. Genomic stability and instability: A working paradigm. In Current Topics in Microbiology and Immunology, Chapter 2, M.B. Kastan (ed.), Springer-Verlag, Berlin, pp. 5-18, 1997.  PMID: 8979437  [View PDF]

• Gestl EE, Kauffman EJ, Moore JL, Cheng KC. New conditions for generation of gynogenetic half-tetrad embryos in the zebrafish, Danio rerio.  J Heredity 88:76-79, 1997.  [View PDF]

• Cheng KC, Moore JL. Genetic dissection of vertebrate processes in zebrafish: A comparison of uniparental and two-generation screens. Biochemistry and Cell Biology 75:525-533, 1997.  PMID: 9551177 [View PDF]

• Cheng KC. A day well-spent for science:  a first experience with Scientific Congressional Advocacy.  The ASCB Newsletter 21(3), April 1998. http://www.ascb.org/news/vol21no3/brief2.htm 

• Cheng K. You can't win the Indy 500 in a Yugo:  Help NSF funding:  An op-ed.  In HMS Beagle:  The BioMedNet Magazine, Issue 28, Apr. 17, 1998.

• Tsao-Wu GS, Weber CH, Budgeon LR, Cheng KC. Agarose embedded tissue arrays for histologic and genetic analysis.  Biotechniques 25:614-618, 1998.  PMID: 9793642  [View PDF]

• Tsao-Wu GS, Weber CH, Budgeon LR, Cheng KC. Agarose embedded tissue arrays for histologic and genetic analysis.  In Expression Genetics:   High-Throughput Methods, Chapter 4, M. McClelland and A. Pardee (eds.), Eaton Publishing, pp. 31-36, 1999.  [View PDF]

• Cheng KC, Beckwith L, Wang X. Update to: Agarose embedded tissue arrays for histological and genetic analysis.  In Expression Genetics:   High-Throughput Methods, M. McClelland and A. Pardee (eds.), Eaton Publishing, p. 37, 1999.  [View PDF]

• Beckwith LG, Moore JL, Tsao-Wu GS, Harshbarger JC, Cheng KC. Ethylnitrosourea induces neoplasms in zebrafish (Danio rerio).  Lab Invest 80:379-385, 2000 (cover article).    PMID: 11956074  [View PDF]

• Mohideen M-APK, Moore JL, Cheng KC. Centromere-linked microsatellite markers for linkage groups 3, 4, 6, 7, 13 and 20 of zebrafish (Danio rerio).  Genomics 67:102-106, 2000.  PMID: 10945477  [View PDF]

• Rajarao SJR, Canfield VA, Mohideen M-APK, Postlethwait JH, Cheng KC, Levenson R.  The repertoire of Na,K-ATPase a and b subunit genes expressed in the zebrafish, Danio rerio.  Genome Research 11:1211-1220, 2001.  PMID: 11435403  [View PDF]

• Moore JL, Aros M, Steudel KG, Cheng KC.  Fixation and decalcification of adult zebrafish for histological, immunocytochemical, and genotypic analysis. Biotechniques 32:296-298, 2002.  PMID: 11848405  [View PDF]

• Gerhard GS, Kaufmann EJ, Wang X, Stewart R, Moore JL, Kasales CJ, Cheng KC.  Life spans and senescent phenotypes in an outbred and an inbred strain of zebrafish (Danio rerio).  Exp. Gerontology 37:1055-1068, 2002.  PMID: 12213556  [View PDF]

• Gerhard GS, Cheng KC.   A call to fins!  Zebrafish as a gerontological model.  Aging Cell 1:104-111, 2002.  [View PDF]

• Mohideen M-APK, Beckwith LG, Tsao-Wu GS, Moore JL, Wong ACC, Chinoy MR, Cheng KC.  Histology-based screen for zebrafish mutants with abnormal cell differentiation. Developmental Dynamics 228:414-423, 2003.  PMID: 14579380  [View PDF]

• Cheng KC, Levenson RL, Robishaw JD. Functional genomic dissection of multimeric protein families in zebrafish.  Developmental Dynamics 228:555-567, 2003.  PMID: 14579392  [View PDF]

• Moore JL, Gestl EE, Cheng KC.  Mosaic eyes, genomic instability mutants, and cancer susceptibility.  Meth Cell Biol 76:555-568, 2004.  PMID: 15602892

• Gerhard GS, Malek RL, Keller E, Murtha J, Cheng KC.  Zebrafish, Killifish, neither fish, both fish?  J Gerontol 59:B873-B875, 2004.  PMID: 15472148  [View PDF]

• Cheng KC.  A life-span atlas for the zebrafish (announcement).  Zebrafish 1:69, 2004. [View PDF]

• Cheng KC.  Zebrafish experts speak (editorial).  Zebrafish 1:85-103, 2004.  [View PDF]

• Ostrander GK, Cheng KC, Wolf JC, Wolfe MJ.  Shark cartilage, cancer and the growing threat of pseudoscience. Cancer Res 64:8485-8491, 2004.  PMID: 15574750  [View PDF]

• Cheng KC.  As I See It: Use science to support global policy.  Harrisburg Patriot-News, December 12, 2004, F1, 6.  [View PDF]

• Duffy KT, McAleer MF, Davidson WR, Kari L, Kari C, Liu C-G, Farber SA, Cheng KC, Mest JR, Wickstrom E, Dicker AP, Rodeck U.  Coordinate control of cell cycle regulatory genes in zebrafish development tested by cyclin D1 knockdown with morpholino phosporodiamidates and hydroxyprolyl-phosophono peptide nucleic acids.  Nucleic Acids Res 33:4914-4921, 2005.  PMID: 16284195   [View PDF]

• Croushore JA, Blasiole B, Riddle RC, Thisse C, Thisse B, Canfield VA, Robertson GP, Cheng KC, Levenson R.  ptena and ptenb genes play distinct roles in zebrafish embryogenesis. Developmental Dynamics 234:911-921, 2005.  PMID: 16193492 [  [View PDF]

• Lamason RL, Mohideen M-AP, Mest JR, Wong AC, Norton HL, Aros MC, Juurynec MJ, Mao X, Humphreville VR, Humbert JE, Sinha S, Moore JL, Jagadeeswaran P, Ning G, Makalowska I, Zhao W, McKeigue PM, O'Donnell D, Kittles R, Parra EJ, Mangini NJ, Grunwald DJ, Shriver MD, Canfield VA, Cheng KC.  SLC24A5 affects pigmentation in zebrafish and man.  Science 310:1782-1786, 2005. (cover article)  PMID: 16357253  [due to the large file size of the supplement and cover, we offer three versions: SciencePaperNoSuppl.pdf (the paper as presented in the journal; 457kb), SciencePaper&Suppl.pdf (the paper in the journal, including the supplementary data; 2857kb), and Science16Dec2005cover.pdf (just the cover, in high resolution, originally submitted with the caption, "Skin color is only gene deep"; 5814kb)].  Science 16 December 2005 "News of the Week".

• Zinnanti WJ, Lazovic J, Wolpert EB, Antonetti DA, Smith MB, Connor JR, Woontner M, Goodman SI, Cheng KC.  A diet-induced mouse model for glutaric aciduria type I.  Brain 129:899-910, 2006.  PMID: 16446282  [View PDF]

• Cheng KC.  The golden mutation in zebrafish.  Commentary #1, February 2006 PASPCR web-site posting.  [View PDF]

• Cheng KC.  Bach's Goldberg Variations: An artistic inspiration for art, science, medicine, and life.  Wild Onions 20:14-15, 2006.  [View PDF]

• Blasiole B, Canfield VA, Mohideen M-APK, Vollrath MA, Huss D, Dickman JD, Cheng KC, Fekete DM, Levenson, RL.  Separate Na,K-Atpase genes are required for otolith formation and semicircular canal development in zebrafish.  Dev Biol 294:148-160, 2006.  PMID: 16566913  [View PDF]

• Zinnanti WJ, Lazovic J, Wolpert EB, Antonetti DA, Smith MB, Connor JR, Woontner M, Goodman SI, Cheng KC.  New insights for glutaric aciduria type I.  Brain 129:E55, 2006.  PMID: 16870880  [View PDF]

• Sabaliauskas NA, Foutz CA, Mest JR, Budgeon LR, Sidor A, Gershenson J, Joshi S, Cheng KC. High-throughput zebrafish histology.  Methods 39:246-254, 2006.  PMID: 16870470  [View PDF]

• Moore JL, Rush LM, Breneman C, Mohideen M-AP, Cheng, KC.  Zebrafish genomic instability mutants and cancer susceptibility.  Genetics 174:585-600, 2006 (October cover article), 2006. PMID: 16888336  [View PDF]

• Cheng KC, Canfield VA. The role of SLC24A5 in skin color. Invest Dermatol 16:836-838, 2006.  [View PDF]

• Chi A, Valencia JC, Hu Z-Z, Watabe H, Yamaguchi H, Mangini NM, Huang H, Canfield VA, Cheng KC, Yang OF, Abe R, Yamagishi S, Shabanowitz J, Hearing VJ, Wu C, Appella E, Hunt DF.  Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.  J Proteome Res 5:3135-3144, 2006.  PMID: 17081065  [View PDF]

• Norton HL, Kittles RA, Parra E, McKeigue P, Mao X, Cheng KC, Canfield VA, Bradley DG, McEvoy B, Shriver MD.  Genetic evidence for the convergent evolution of light skin in Europeans and East Asians.  Molecular Biol Evol 24:710-722, 2007.  PMID: 17182896  [View PDF]

• Zinnanti WJ, Lazovic J, Housman C, LaNoue K, O'Callaghan JP, Simpson I, Woontner M, Goodman SI, Connor JR, Jacobs RE, Cheng KC.  Mechanism of age-dependent susceptibility and novel treatment strategy in glutaric acidemia type I.  J Clin Invest 117:3258-3270, 2007.  PMID: 17932566  [View PDF]

• Canada BA, Thomas GK, Cheng KC*, Wang JZ.*  Automated segmentation and classification of zebrafish histology images for high-throughput phenotyping.  Proceedings of the Third IEEE-NIH Life Science Systems and Applications Workshop, pp. 245-248, Washington, D.C., November 2007.  (*equal contributors)  ISBN number: 978-1-4244-1813-8  [View PDF]

• Cheng KC.  Demystifying Skin Color and "Race".  In R.E. Hall (ed.):  Racism in the 21st Century, Chapter 1, pp. 3-23, Springer, 2008.

FREQUENTLY ASKED QUESTIONS

What is your goal in life?

Pigmentation Research:

What might your work in human pigmentation contribute to human health?

What do you hope the pigment gene discovery might contribute to society?

What have been the most common public misconceptions about skin color?

Will it be at all possible to change a person’s skin color from white to black or black to white in the near future? Or do you think your discovery can allow people to have a choice in what skin tone they have?

Does the work on SLC24A5 bring us closer to a cure for vitiligo?

I heard that you met with the Race, Ethnicity, and Genetics Working Group at the National Human Genome Research Institute at NIH.  What were your conclusions?

Tell us more about mutation and evolution.

Is there any direct evidence that SLC24A5 is related to intelligence?

Is there anything not talked about with regard to the skin pigmentation work you would like to point out?

When did you become interested in genomic instability?

When did you decide to use zebrafish as a cancer model?

What is your training philosophy?

What is required of graduate students for graduation?

How long will graduate school take?

What is required for success in graduate school?

What is expected of postdoctoral fellows?

How and when did you think of your histology screen?

Explain your interest in Functional Genomics.

When did you become interested in cancer research?

How is it that you came to Penn State?

Who are you willing to hire, when?

I heard you are a musician.  Tell us about it.

What is MUSIC for JAKE, and are you playing again?

Why are you on the Board of Directors of WITF?

What is the Kienle Series?

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NEW!!

Skin Color Audiovisuals

Dr. Keith Cheng

was the recipient of the
2008 Penn State Faculty Scholar Medal
for Outstanding Achievement
in Life and Health Sciences
on March 24, 2008

  Science Paper 16 Dec 2005
  Science Paper and Supplement
  Science Cover Image
  Science News of the Week
  PSU Live Press Release

Penn State Mini-Medical School Genetics Lecture
Presented by Dr. Keith Cheng

 "The Genetic Basis of Skin Color"