Anatomic Pathology

Dani S. Zander, M.D. Professor and Chair, Department of Pathology University Chair in Pathology
	Office:  Room C7710A Telephone:  (717) 531-8351 Pager:  4311-3063 Fax:  (717) 531- 5021 Email: dzander@hmc.psu.edu     Area of interest:  Clinical: Pulmonary pathology, anatomic pathology Research: Pulmonary pathology, stem cells, lung cancer, transplantation

Dr. Zander became Chair of our department in June, 2006.  Prior to this, she served as tenured Professor, Vice Chair, and Director of Anatomic Pathology at University of Texas Health Science Center at Houston Medical School where she was named the endowed Harvey S. Rosenberg Chair in Pathology and Laboratory Medicine, and was a member of the faculty at the University of Florida College of Medicine where she held the position of Chief of Anatomic Pathology at the Malcom Randall Veterans Affairs Medical Center. She is an elected member of the Council of the American Society of Investigative Pathology, for which she also chairs the Committee for Career Development, Women & Minorities. She is also active in the United States and Canadian Academy of Pathology, the Pulmonary Pathology Society, and the Association of Clinical Scientists.  She serves on the editorial boards of CHEST and Annals of Clinical and Laboratory Science, and has been invited to serve on multiple peer review panels for Department of Defense research programs. 

Dr. Zander is also a practicing pathologist with subspecialty expertise in pulmonary pathology.  For many years, she has maintained a consult service in this area, accepting difficult pulmonary pathology cases referred to her for second opinions.  Her research is focused primarily on pulmonary pathology, particularly in the areas of stem cell biology, transplantation, and cancer.  She enjoys working with residents on clinical services and research projects, and many of these research projects have led to presentations at national and international meetings, particularly the USCAP and ASCP.  In 2006, two of these projects also received awards at the state medical society poster and podium presentation competitions.  Residents are welcomed and encouraged to talk with her about becoming involved in research projects, whether in lung pathology or another area of interest.

Education and Certification:

B.A. in Chemistry, New York University, New York, NY, 1982

M.D., University of Florida College of Medicine, Gainesville, FL, 1986

Internship in Pathology, The New York Hospital – Cornell University Medical Center, New York, NY, 1986 – 1987

Residency in Anatomic and Clinical Pathology, University of Florida College of Medicine, Gainesville, FL, 1987 – 1991

Certifications:
    1987    National Board of Medical Examiners
    1991    American Board of Pathology Certification in Anatomic and Clinical Pathology
    1997    American Board of Pathology Certification in Cytopathology

Publications (selected):

Original Articles (Refereed):

• Cogle CR, Yachnis AT, Laywell ED, Zander DS, Wingard JR, Steindler DA, Scott EW.  Bone marrow transdifferentiation in brain after transplantation: a retrospective study.  Lancet 363:1432-1437, 2004.

• Visner GA, Faro A, Zander DS.  Role of transbronchial biopsies in pediatric lung diseases.  CHEST 126:273-280, 2004.

• Bonnell MR, Visner GA, Zander DS, Mandalapu S, Kazemfar K, Spears L, Beaver TM.  Heme oxygenase-1 expression correlates with severity of acute cellular rejection in lung transplantation.  J Am Coll Surg 198:945-952, 2004. 

• Zhou H, Lu F, Latham C, Zander DS, Visner GA.  Heme oxygenase-1 in human lungs with cystic fibrosis and cytoprotective effects against Pseudomonas aeruginosa.  Am J Respir Crit Care Med 170:633-640, 2004. 

• Zhang H, Liu J, Cagle PT, Allen TC, Laga AC, Zander DS.  Distinction of pulmonary small cell carcinoma from poorly differentiated squamous cell carcinoma: An immunohistochemical approach.  Mod Pathol 18:111-118, 2005.   

• Zhou H, Latham CW, Zander DS, Margolin SB, Visner GA.  Pirfenidone inhibits obliterative airway disease in mouse tracheal allografts.  J Heart Lung Transplant 24:1577-1585, 2005.

• Zander DS, Baz MA, Cogle CR, Visner GA, Theise ND, Crawford JM.  Bone marrow-derived stem cell repopulation contributes minimally to the type II pneumocyte pool in transplanted human lungs. Transplantation 80:206-212, 2005.

• Laga A, Zander DS, Cagle PT.  Prognostic significance of cyclooxygenase-2 expression in 259 cases of non-small cell lung cancer.  Arch Pathol Lab Med 129:1113-1117, 2005.

• Sienko A, Allen TC, Zander DS, Cagle PT.  Frozen section of lung specimens.  Arch Pathol Lab Med 129:1602-1609, 2005.

• Granville L, Laga AC, Allen TC, Dishop M, Roggli VL, Churg A, Zander DS, Cagle PT.  Review and update of uncommon primary pleural tumors: a practical approach to diagnosis.  Arch Pathol Lab Med 129:1428-1443, 2005.

• Zander DS, Cogle CR, Theise ND, Crawford JM.  Donor-derived type II pneumocytes are rare in the lungs of bone marrow transplant recipients.  Ann Clin Lab Sci 36:47-52, 2006.

• Butnor KJ, Nicholson AG, Allred DC, Zander DS, Henderson DW, Barrios R, Haque AK, Allen TC, Killen DE, Cagle PT:  Expression of renal cell carcinoma-associated markers EPO, CD10, and RCCMa in malignant mesothelioma and metastatic renal cell carcinoma.  Arch Pathol Lab Med 130:823-827, 2006.

• Kalhor N, Zander DS, Liu J.  TTF-1 and p63 for distinguishing pulmonary small cell carcinoma from poorly differentiated squamous cell carcinoma in previously pap-stained cytologic material.  Mod Pathol 19:1117-1123, 2006.

• Andino L, Cagle PT, Murer B, Lu L, Popper HH, Galateau-Salle F, Sienko A, Barrios R, Zander DS:  Pleuropulmonary desmoid tumors: Immunohistochemical comparison with solitary fibrous tumors and assessment of β-catenin and cyclin D1 expression.  Arch Pathol Lab Med 130:1503-1509, 2006.

• Allen TC, Granville LA, Cagle PT, Haque A, Zander DS, Barrios R.  Expression of glutathione S-transferase pi and glutathione synthase correlates with survival in early stage non-small cell carcinomas of the lung. Hum Pathol 38:220-227, 2007.

• Kwon K, Zander D, Killen D, Sienko A, Barrios R, Haque A, Ro J.  MUC4 expression in non-small cell lung carcinomas: Relationship to tumor histology and patient survival.  Arch Pathol Lab Med (in press).

Invited Articles (Refereed):

• Zander DS.  Idiopathic interstitial pneumonias and the concept of the trump card. CHEST 125:359-360, 2004.

• Zander DS.  Core roll preparations and the pathologist as consultant. CHEST 126:664-666, 2004.

• Zander DS.  Allergic bronchopulmonary aspergillosis: An overview.   Arch Pathol Lab Med 129:924-928, 2005.

• Zander DS.  Bronchoscopic cytology: Expanding the menu.  CHEST 130:634-635, 2006.

Book Chapters:

• Zander DS.  Transplant-related pathology. In Cagle PT (ed.): Diagnostic Pulmonary Pathology.  Marcel Dekker, Inc., New York, NY, 2000, pages 461-484.

• Zander DS.  Transplantation-associated arteriosclerosis and inflammation. In Mehta JL (ed.): Inflammatory and Infectious Basis of Atherosclerosis.  Birkhauser Verlag, Basel, Switzerland, 2001, pages 61-78.

• Zander DS.  Multiple chapters (38 in total).  In Cagle PT (ed.): Color Atlas and Text of Pulmonary Pathology. Lippincott, Williams, and Wilkins, Philadelphia, PA, 2004. 

• Zander DS.  Transplantation pathology.  In Tomashefski J (ed.):  Dail and Hammar’s Pulmonary Pathology, third edition.  Springer-Verlag, New York, NY (in press).

• Zander DS.  Stem cells in non-neoplastic lung disorders.  In Zander D, Popper H, Jagidar J, Haque A, Cagle PT, Barrios R (eds): Molecular Pathology of Lung Diseases, Springer (in press).

• Tan D, Zander DS.  Techniques and applications to the diagnosis of lung diseases: Immunohistochemistry.  In Zander DS, Farver C (eds.): Pulmonary Pathology.  Elsevier, Philadelphia, PA (in press).

• Allison A, Zander DS.  Drug reactions and other iatrogenic lung diseases.  In Zander DS, Farver C (eds.): Pulmonary Pathology.  Elsevier, Philadelphia, PA (in press).

• Chughtai O, Zander DS.  Pulmonary manifestations of systemic diseases.  In Zander DS, Farver C (eds.): Pulmonary Pathology.  Elsevier, Philadelphia, PA (in press).

Books – Editorial:

• Cagle PT, Allen T, Barrios R, Bedrossian C, Haque A, Laga A, Ostrowski M, Zander DS (eds.).  Color Atlas and Text of Pulmonary Pathology.  Lippincott, Williams, and Wilkins, Philadelphia, PA, 2004. 

• Zander DS, Farver C (eds.).  Pulmonary Pathology.  Elsevier, Philadelphia, PA (in press).

• Zander DS, Popper H, Jagirdar J, Haque A, Cagle PT, Barrios R (eds.):  Molecular Pathology of Lung Diseases.  Springer-Verlag, New York, NY (in press). 

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