Anatomic Pathology

John J. Liang, M.D. Assistant Professor, Division of Anatomic Pathology
	Office:  Room C7628B Telephone: (717) 531-7413; (717) 531-8246 Pager:  4311-5105 Fax: (717) 531-7741 Email: jliang1@hmc.psu.edu     Areas of interest:  GI, liver, pancreatic and renal pathology

Dr. John Liang joined the HMC/PSU College of Medicine in 2007.  His interests in pathology include general surgical pathology, especially GI, liver, pancreas and renal pathology.   He enjoys teaching medical students, residents and fellows.  His research interests are molecular mechanisms and prognostic biomarkers in GI, liver and pancreatic diseases.

Education and Certification:

M.D., Anhui Medical University, Hefei, China, 1985

Residency, Anatomic Pathology and Clinical Pathology, New York University School of Medicine, New York, 2002

Fellowship, GI, Liver and Pancreatic Pathology,  U.T.M.D. Anderson Cancer Center, Houston, TX , 2007

Publications (selected):

• Liang J, Sipe JD.  Recombinant human serum amyloid A (apoSAAp) binds cholesterol and modulates cholesterol flux. J Lipid Res 36:37-46, 1995.

• Liang J,  Shreiber B, Salmona M, Phillip G, Gonnerman WA, de Beer FC, Sipe JD.   The amino terminal region of acute phase, but constitutive, serum amyloid A (apoSAA) specifically binds and transports cholesterol into aortic smooth muscle and Hep G2 cells.  J Lipid Res 37:2109-2116, 1996.

• Liang J, Fine RE, Abraham CR, Sipe JD.   The fibril formation region of the β-amyloid precursor differs from that of the amyloid A precursor in its interaction with lipids.  Biochem Biophy Res Commun 219:962-967, 1996.

• Liang J, Sloan J, Wells J, Abraham CR, Fine RE, Sipe JD. Local expression of the acute phase response protein serum amyloid A in Alzheimer’s disease brain.   Neurosci  Lett 225:73-76, 1997.

• Liang J, Wu X, Jiang HX, Zhou MY, Huang LX, Sturley S, Ginsberg HN. Translocation efficiency, susceptibility to proteasome degradation, and lipid responsiveness of apolipoproteinB are determined by the presence of beta sheet domains.  J Biol Chem 273:35216-35221, 1998.

• Liang J, Elliott-Bryant R, Hajri T, Sipe JD, Cathcart ES. A unique amyloidogenic apolipoprotein serum amyloid A (apoSAA) isoform expressed by the amyloid resistant CE/J mouse strain exhibits higher affinity for macrophages than apoSAA1 and apoSAA2 expressed by amyloid susceptible CBA/J mice.  Biochim Biophys Acta 2:121-126, 1998.

• Liang J,  Wu XY, Fisher EA, Ginsberg HN. The amino-terminal domain of apoB does not undergo retrograde translocation from the ER to the cytosol:  Proteasomal degradation of nascent apoB begins at the carboxyl-terminus of the protein while apoB is still in its original translocon.  J Biol Chem  275:32003-32010, 2000.

• Pan MH, Liang J, Fisher EA, Ginsberg HN. Inhibition of translocation of nascent apolipoprotein B across the reticulum membrane is associated with selective inhibition of the synthesis of apolipoprotein B.  J Biol Chem 275:27399-27405, 2000.

• Liang J, Distler O, Cooper D, Deckelbaum R, Sturley S, Ginsberg HN.  HIV protease inhibitors protect apolipoprotein B from degradation by the proteasome: a potential mechanism for protease inhibitor-induced hyperlipidemia.  Nature Medicine 7:1327-1331, 2001.

• Liang J and Ginberg HN. Microsomal triglyceride transfer protein binding and lipid transfer activities are independent of each other, but both are required for secretion of apolipoprotein B lipoproteins from liver cells.  J Biol Chem 276:28606-28612, 2001.

• Liang J, Kim T, Fang S, Yamaguchi J, Weissman AM, Fisher EA, Ginsberg HN. Overexpression of the tumor autocrine motility factor receptor Gp78, a ubiquitin protein ligase, results in increased ubiquitinylation and decreased secretion of apolipoprotein B100 in HepG2 cells.  J Biol Chem 278(26):23984-23988, 2003.

• Liang J, Oelkers P, Guo C, Chu P,Dixon JL, Ginsberg HN, Sturley SL.  Overexpression of human diacylglycerol acyltransferase 1, acyl-CoA:cholesterol acyltransferase 1 or acyl-CoA:cholesterol acyltransferase 2 stimulates secretion of apolipoprotein B-containing lipoproteins in McA-RH7777 cells.  J Biol Chem 279(43):44938-44944, 2004.

• Liang J, Wang ZX, Chiriboga L, Greco MA, Shapiro E, Huang HY, Huang JD, Melamed J, Lee P.  The expression and function of androgen receptor coactivator p44 and protein arginine methyltransfersase 5 (PRMT5) in the developing testis and testicular tumors.  J Urology 177:1918-1922, 2007.

• Liang J, Mittal K, Wei J, Yee H, Shukla P:  Utility of p16, CEA, Ki67, p53 and ER/PR in the differential diagnosis of benign, premalignant and malignant glandular lesions of the uterine cervix and their relationship with Silverberg scoring system for endocervical glandular lesions.  Int J Gynecol Pathol 26:71-75, 2007.

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