Neuroscience Research Institute

Faculty Biosketch                           Milton S. Hershey Medical Center
                                                                       Penn State College of Medicine
                                                                       P.O. Box 850,
                                                                       500 University Drive
                                                                       Hershey, PA 17033-2390

Neal J. Thomas, M.D., M.Sc. Pediatric Critical Care Medicine	Office Information Phone: 717-531-5337 Mail Code: H085 E-Mail: nthomas@psu.edu
Education
B.S., University of Scranton, 1987 M.D., Temple University, 1991 Residency, Medical University of South Carolina, 1991-1994 Post Doc, Children's Hospital of Pittsburgh, 1995-1998 Master of Science in Health Evaluation Sciences, Penn State College of Medicine 2002-2004
Primary Area of Interest
Inflammatory changes after traumatic brain injury in children

Research Focus

We a part of a collaborative effort (with Children's Hospital of Pittsburgh and just recently with Children's National Medical Center, Washington, D.C.) aimed at understanding the inflammatory changes that occur during traumatic brain injury in children. Our focus has been on tracking serial alerations of inflammatory markers in cerebral spinal fluid of children who require intensive neurocritical care for severe traumatic brain injury.

We are also part of the Pediatric Traumatic Brain Injury Consortium, which has been founded to carry out clinical research of therapeutic trials aimed at improving outcome in severe head injury in children. The first randomized clinical trial of this group will examine the role of moderate hypothermia in children with severe traumatic brain injury.

References

1. Thomas NJ, Janesco KL, Ceneviva GC, Lucking SL, Dettorre MD, Adelson PD, Kochanek PM. Chemokine response in cerebral spinal fluid after severe traumatic brain injury in infants and children. Crit Care Med 2001; 29(12, Suppl): A6.

2. Fink EL, Satchell MA, Kochanek PM, Jenkins LW, Janesko KL, Thomas NJ, Adelson PD, Clark RSB. Cerebrospinal fluid analysis of hepatocyte growth factor concentration in infants and children after traumatic brain injury. Crit Care Med 2001; 29(12, Suppl): A140.

3. Shore PM, Varma S, Berger RP, Janesko KL, Wisniewski SR, Clark RSB, Adelson PD, Thomas NJ, Lai YC, Bayir H, Kochanek PK: Glasgow coma scale score does not correlate with markers of brain injury in cerebrospinal fluid of infants and toddlers after traumatic brain injury. Crit Care Med 2003; 31(12, Suppl): A91.

4. Varma S, Janesko KL, Wisniewski SR, Bayir H, Adelson PD, Thomas NJ, Kochanek PM: F2-isoprostane and neuron-specific enolase in cerebrospinal fluid after severe traumatic brain injury in infants and children. J Neurotrauma, 2003; 20: 781-786.

5. Shore PM, Thomas NJ, Clark RSB, Adelson PD, Wisniewski SR, Janesko KL, Bayir H, Jackson EK, Kochanek PM. Continuous vs. intermittent cerebrospinal fluid drainage after severe traumatic brain injury in children: effect on biochemical markers. J Neurotrauma, 2004; 21 (9): 1113-1122.

6. Berger RP, Heyes MP, Wisniewski SR, Adelson PD, Thomas NJ, Kochanek PM: Assessment of the macrophage marker quinolinic acid in cerebrospinal fluid after pediatric traumatic brain injury: Insight into the timing and severity of injury in child abuse. J Neurotrauma, 2004; 21 (9): 1123-1130.

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Faculty Biosketch Milton S. Hershey Medical Center Penn State College of Medicine P.O. Box 850, 500 University Drive Hershey, PA 17033-2390

Faculty Biosketch Milton S. Hershey Medical Center
Penn State College of Medicine
P.O. Box 850,
500 University Drive
Hershey, PA 17033-2390