Mark Diaz, M.D. - Biosketch

Neuroscience Research Institute

Faculty Biosketch	Milton S. Hershey Medical Center Penn State College of Medicine P.O. Box 850, 500 University Drive Hershey, PA 17033-2390

Gregory Moore, M.D., Ph.D. Professor, Department of Psychiatry and Neural and Behavioral Sciences Director - Behavioral Neuroimaging Research Division		Office Information Phone: 717-531-8646 Mail Code: H073
Education
B.S., Physics/Biology, North Park College, Chicago, IL, 1986 S.M. Nuclear Engineering, Massachusetts Institute of Technology, Cambridge, MA, 1988 Ph.D., Radiological Sciences, Massachusetts Institute of Technology, Cambridge, MA, 1992 M.D., Wayne State University School of Medicine, Detroit, MI M.D. 2004 Residency, Penn State Milton S. Hershey Medical Center-Diagnostic Radiology, 2004-2009 Post-Doc, Biomedical NMR research Lab, University of California, Los Alamos National Laboratory, Los Alamos, NM, 1992-1994 Other Training: Gordon Conwell Theological Seminary South Hamilton, MA Graduate Studies in Systematic Theology 1990-1991
Primary Area of Interest
Neuroimaging Biomarkers
Research Focus
The mission of the Behavioral Neuroimaging Research Division is to lead the discovery and development of neuroimaging biomarkers utilizing advanced neuroimaging tools coupled with powerful bioinformatics technology to improve diagnosis, guide pharmacologic and behavioral interventions, and predict treatment response in children and adults devastated by severe Neuropsychiatric illness and Neurodegenerative Disorders. Specifically this task involves the delineation and validation of in vivo neuroimaging biomarkers of molecular events. Pre-clinical neuroscience research and clinical research studies are centered within the research division which utilizes “state of the art” neuroimaging tools including advanced 3D morphometric magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS), and functional MRI (fMRI) to investigate brain structure, neurochemistry and function, respectively. Facilities include 3T Human MR, 7T animal MR, and PET/CT. In addition, the division houses advanced high performance computing and bioinformatics technology for data analyses. Additional collaborative research investigations are carried out at the National Institutes of Health, Bethesda, MD, Wayne State University School of Medicine, Detroit, MI, and at the VA Medical Center, Lebanon, PA. Areas of active clinical neuroimaging research investigation in pediatric and adult subjects include: Bipolar Disorders, Anxiety Disorders, Depression, PTSD, Autism, Eating Disorders, Sleep Disorders, Restless Leg Syndrome, Alzheimer’s Disease and Suicide Prevention. Areas of active preclinical and basic neuroscience neuroimaging investigation include Monitoring of Pharmacologic Modulation of Neurochemistry, Effects of Stress on Neurochemistry/Brain Structure, and Neuroprotective/Neurotrophic Effects. In addition to the research mission, members of the division are actively involved in professional consultation, education and outreach activities locally, statewide, nationally and internationally.
References

Selected peer reviewed journal references (from a total of 65)

1. Yoshizawa T, Nose T, Moore GJ, Sillerud LO, Functional Magnetic Resonance Imaging of Motor Activation in the Human Spinal Cord at the Mid-Cervical Level, NeuroImage 4:174-182 (1996).

2. Gonzalez RG, Guimaraes AR , Moore GJ, Crawley A, Cupples LA, Growdon JH, Quantitative in vivo 31P magnetic resonance spectroscopy of Alzheimer disease, Alzheimer Disease & Associated Disorders, 10(1):46-52, (1996).

3. Moore GJ, Slovis TL, Chugani HT, Proton Magnetic Resonance Spectroscopy in Children with Sturge-Weber syndrome, Journal of Child Neurology, 13(7): 332-335 (1998).

4. Moore GJ, Proton Magnetic Resonance Spectroscopy in Pediatric Neuroradiology, Pediatric Radiology, , 28:805-814 (1998).

5. Chugani DC, Sundram BS, Behen M, Lee ML, Moore GJ, Evidence of Altered Energy Metabolism in Autistic Children, Prog. Neuro-Psychopharmacol. & Biol. Psychiat., 23:635-641 (1999).

6. Moore GJ, Bebchuk JM, Parrish JK, Faulk MW, Arfken CL, Strahl-Bevacqua J, Manji HK, Temporal Dissociation Between Lithium Induced Frontal Lobe Myo-Inositol Changes and Clinical Response in Manic Depressive Illness, American Journal of Psychiatry, 156(12): 1922-1931(1999).

7. Moore GJ, Bebchuk JM, Hasanat K, Faulk MW, Seraji-Bozorgzad N, Wilds IB, Arfken CL, Chen G, Manji HK Lithium Increases N-acetyl-aspartate in the Human Brain: In Vivo Evidence In Support of bcl-2’s Neurotrophic Effects?, Biological Psychiatry, 48(1):1-8, (2000).

8. Gilbert AR, Moore GJ, Keshavan MS, Paulson LA, Narula V, Mac Master FP, Stewart CM, Rosenberg DR, Decrease in thalamic volumes of pediatric patients with obsessive-compulsive disorder who are taking paroxetine, Archives of General Psychiatry, 57(5):449-56 (2000).

9. Pfund Z, Chugani DC, Juhasz C, Muzik O Chugani HT, Wilds IB, Seraji-Bozorgzad N, Moore GJ, Evidence for Coupling Between Glucose Metabolism and Glutamate Cycling Using FDG PET and 1H MRS in Epilepsy, Journal of Cerebral Blood Flow and Metabolism, 20(5):871-8 (2000).

10. Rosenberg DR, MacMaster FP, Keshavan MS, Fitzgerald KD, Stewart CM, Moore GJ, Decrease in Caudate Glutamatergic concentrations in Pediatric Obsessive-Compulsive Disorder Patients Taking Paroxetine, Journal American Academy of Child and Adolescent Psychiatry, 39(9):1096-1103 (2000).

11. Manji HK, Moore GJ, Chen G, Clinical and preclinical evidence for the neurotrophic effects of Mood Stabilizers: implications for the pathophysiology and treatment of manic depressive illness, Biological Psychiatry, 48(8):740-754 (2000).

12. Manji HK, Moore GJ, Rajkowska G, Chen G, Neuroplasticity And Cellular Resilience in Mood Disorders, Molecular Psychiatry, 5(6):578-593 (2000).

13. Moore GJ, Bebchuk JM, Wilds IB, Chen G, Manji HK, Lithium-Induced Increase in Human Brain Grey Matter, Lancet, 356(9237):1241-1242 (2000).

14. Manji HK, Moore GJ, and Chen G Bipolar disorder: leads from the molecular and cellular mechanisms of action of mood stabilizers. Br J Psychiatry 178, S107-S119 (2001).

15. Keenan PA, Ezzat WH, Ginsburg K, and Moore GJ Prefrontal cortex as the site of estrogen's effect on cognition. Psychoneuroendocrinology 26, 577-590 (2001).

16. Rosenberg DR, MacMillan SN, and Moore GJ Brain anatomy and chemistry may predict treatment response in pediatric obsessive--compulsive disorder. Int J Neuropsychopharmacol 4, 179-190 (2001).

17. Garbern JY, Yool DA, Moore GJ, Wilds IB, Faulk MW, Klugmann M, Nave KA, Sistermans EA, van der Knaap MS, Bird TD, Shy ME, Kamholz JA and Griffiths IR Patients lacking the major CNS myelin protein, Proteolipid protein 1, develop length-dependent axonal degeneration in the absence of demyelination and inflammation Brain 125:551-561 (2002).

18. Nolan C., Moore G.J., Madden R., Farchione T., Bartoi M., Lorch E., Stewart C.M., Rosenberg D.R (2001) Prefrontal Cortical Volume in Childhood-Onset Major Depression: Preliminary findings Archives General Psychiatry 59(2):173-9 (2002).

19. Moore GJ, Galloway MP. Magnetic Resonance Spectroscopy: Neurochemistry and Treatment Effects in Affective Disorders. Psychopharmacology Bulletin 36 (2): 5-23 (2002).

20. Farchione TR, Moore GJ, Rosenberg DR, Proton Magnetic Resonance Spectroscopic Imaging in Pediatric Major Depression, Biological Psychiatry, 52(2):86-92 (2002).

21. Manji HK, Zhou R, Moore GJ, Gray N, Du J, Chen G, Genomic Studies Identify novel targets for the long term actions of mood stabilizers, European Neuropsychopharmacology 12:S132-133 (2002).

22. Nolan CL, Moore GJ, Madden R, Farchione T, Bartoi M, Lorch E, Stewart CM, Rosenberg DR, Reduced Left Prefrontal Cortical Volum : An Early Marker of Familial Pediatric Major Depression?, Archives of General Psychiatry, 59(2): 173-9 (2002)

23. Gray NA, Zhou R, Du J, Moore GJ, Manji HK, The use of mood stabilizers as plasticity enhancers in the treatment of neuropsychiatric disorders, Journal of Clinical Psychiatry, 64: S5:3-17 (2003).

24. Chu A, Alger JR, Moore GJ, Posse S, Proton-Echo-Planar-Spectroscopic-Imaging with Highly Effective Outer Volume Suppression using Combined Presaturation and Spatially Selective Echo Dephasing, Magnetic Resonance in Medicine, 49(5):817-21 (2003).

25. Posse S, Fitzgerald D, Gao K, Habel U, Rosenberg D, Moore GJ, Schneider F, Real-time Functional Magnetic Resonance Imaging of Temporolimbic Regions Detects Amygdala Activation during Single Trial Self-Induced Sadness, Neuroimage 18(3): 760-768 (2003).

26. Benazon NR, Moore GJ, Rosenberg DR, Neurochemical Analyses in Pediatric Obsessive-Compulsive Disorder in Patients Treated With Cognitive-Behavioral Therapy, J Am Acad Child Adolesc Psychiatry, 42(11):1279-1285 (2003).

27. Szeszko PR, MacMillan S, McMeniman M, Chen S, Baribault K, Lim KO, Ivey J, Rose M, Banerjee SP, Bhandari R, Moore GJ, Rosenberg DR. Brain Structure abnormalities in psychotropic drug-naļve pediatric patients with OCD. Am J Psychiatry. 161(6): 1049-56 (2004).

28. Phan KL, Fitzgerald D, Gao K, Moore GJ, Tancer ME, Posse S, Real-time fMRI of cortico-limbic brain activity during emotional processing, NeuroReport, 15(3): 527-32 (2004). 29. Phan KL, Fitzgerald DA, Cortese BM, Seraji-Bozorgzad N, Tancer ME, Moore GJ. Anterior cingulate neurochemistry in social anxiety disorder: 1H-MRS at 4 Tesla. NeuroReport. 16(2): 183-186 (2005).

30. Phan KL, Fitzerald DA, Nathan PJ, Moore GJ, Uhde TW, Tancer ME. Neural substrates for voluntary suppression of negative affect: A functional magnetic resonance imaging, Biological Psychiatry, 57(3): 210-219 (2005).

31. Rosenberg DR, Macmaster FP, Mirza Y, Smith JM, Easter PC, Banerjee SP, Bhandari R, Boyd C, Lynch M, Rose M, Ivey J, Villafuerte RA, Moore GJ, Renshaw P. Reduced anterior cingulate glutamate in pediatric major depression: a magnetic resonance spectroscopy study. Biol Psychiatry. 2005 Nov 1;58(9):700-4.

32. Macmaster FP, Russell A, Mirza Y, Keshavan MS, Banerjee SP, Bhandari R, Boyd C, Lynch M, Rose M, Ivey J, Moore GJ, Rosenberg DR. Pituitary Volume in Pediatric Obsessive-Compulsive Disorder. Biol Psychiatry. 2006 Feb 1;59(3):252-7

33. Bustillo J, Barrow R, Paz R, Tang J, Seraji-Bozorgzad N, Moore GJ, Bolognani F, Lauriello J, Perrone-Bizzozero N, Galloway MP. Long-Term Treatment of Rats with Haloperidol: Lack of an Effect on Brain N-Acetyl Aspartate Levels. Neuropsychopharmacology. 2006 Apr;31(4):751-6.

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Gregory Moore, M.D., Ph.D.

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