Penn State College of Medicine
PSU  I   Calendar  I   News  I   Contact Us  I   Help  I   Search
 
 

 

 

 
 

Neuroscience Research Institute

Faculty Biosketch

 Milton S. Hershey Medical Center
Penn State College of Medicine
P.O. Box 850, 
500 University Drive
Hershey, PA 17033-2390

David C. Good, M.D.

Department of Neurology

  

Office Information

Phone: 717-531-1803
Mail Code: H037
Education
B.S., University of Wisconsin, Madison, 1970
M.D., University of Wisconsin, Madison, 1974
Residency, University of Minnesota, Neurology, 1978
Stroke Fellowship, University of Minnesota, 1978-79
Primary Area of Interest
Neurorehabilitation, Neural Recovery, Clinical Trials to Enhance Function
Research Focus
My major interest is in recovery following stroke and brain injury. I have recently participated in several trials to enhance motor recovery from stroke, including pharmacological agents and training paradigms. As part of the NIH funded EXCITE trial (the first large multicenter randomized trial of a specific training program for stroke), we studied the effects of constraint-induced movement therapy (CIMT). Our companion study used functional MRI and transcranial magnetic stimulation to evaluate changes in cortical excitability and cortical motor networks following CIMT. Another multicenter study (still underway) is evaluating d-amphetamine coupled with intensive training to enhance motor recovery following stroke. I currently chair the Steering Committee of the NIH Traumatic Brain Injury Clinical Trials Network, which will be launching a large multicenter trial of cdp-choline to enhance cognitive outcomes in acute TBI.
References
Recent Abstracts
  1. Goldstein LB, Jones M, Chilukuri V, Matcher DB, Good DC, Feussner JR, Horner R. Computerized Algorithm for Stroke Subgroup Classification Using the TOAST Criteria. Neurology 1999; 52(Suppl 2):A243.
  2. Bastings EP, Yen Y-F, Hammond GL, Burdette JH, Gage HD, Greenberg JP, Moody DM, Hernandez L, Good DC, McDermott SS, Pons TP. Serial co-registration study of functional magnetic stimulation mapping during motor recovery after stroke. Stroke 2000; 31:290.
  3. Bastings EP, Hammond GL, Good DC, Greenberg JP, McDermott SS, Pons TP. Decrease of intracortical inhibition in the unaffected hemisphere after unilateral stroke: Evidence from a paired-pulse magnetic stimulation study. Stroke 2000; 31:300.
  4. Goldstein LB, Dromerick AW, Good DC, Lennihan L, McDowell F, Reding MJ, Samsa GP. Multicenter study of post-stroke neurorehabilitation: Implications for trial design. Stroke 2000; 31:303.
  5. Gelber DA, Good DC, Dromerick A, Richardson M. An open-label dose titration safety and efficacy study of Zanaflex® (tizanidine HCl) in the treatment of chronic spasticity associated with stroke. Stroke 2000; 31:314.
  6. Scales C, Greenberg JP, Wittenberg G, Bastings E, Good DC, Pons TP. Correlation of TMS motor threshold with clinical outcome measures in stroke patients. Neurorehab Neural Repair 2001; 15:89.
  7. Yen Y-F, Bastings E, Burdette J, Scales C, Williams C, Greenberg J, Wittenberg G, Good D, Pons T. Longitudinal evaluation of activation of primary motor cortex with fMRI on subcortical stroke patients during recovery. NeuroImage 2001; 13(6): S1281.
  8. Wittenberg GF, Bastings EP, Scales C, Good DC. Evolution of transcranial magnetic stimulation motor maps during recovery after stroke. NeuroImage 2001; 13 (6): S5853.
  9. Lennihan L, Dromerick AW, Goldstein LB, Good DC, McDowell F, Reding MJ, Samsa GP. Predictors of recovery of arm function during stroke rehabilitation. Neurorehab Neural Repair. 2001; 15:357.
  10. Good DC. Physician Training in Neurorehabilitation. Neurorehab Neural Repair. 2001; 15:364.
  11. Greenberg JP, Williams CB, Wittenberg GF, Bastings EP, Yen Y-F, Pons TP, Good DC. Serial functional magnetic resonance imaging of upper extremity motor function after stroke. Neurology. 2002; 58 (Suppl 3):A30.
  12. Wittenberg GF, Williams CB, Scales C, Good DC. 3D Projection onto cortex of transcranial magnetic stimulation motor maps during recovery from stroke. Neurology. 2002; 58 (Suppl 3):A4-A5.
  13. Goldstein LB, Dromerick AW, Good DC, Lennihan L, McDowell F, Reding M, Samsa GP. Possible time window for the detrimental effects of drugs on post stroke recovery. Neurology. 2002; 58 (suppl 3):A5-A6
  14. Greenberg JP, Yen Y-F, Scales C, Williams C, Bastings EP, Wittenberg GF, Pons TP, Good DC. Serial magnetic resonance imaging of motor function after stroke. Stroke. 2002; 33:417.
  15. Smith S, Bastings EP, Morgan T, Pons T, Good DC, Wittenberg GF. Paired-pulse inhibition and facilitation of motor evoked potentials after cerebral infarction: A longitudinal study with transcranial magnetic stimulation. Soc. For Neuroscience Ann Mtg, 2002; Abstract 562.8.
  16. Sawaki L, Butler AJ, Wasserman P, Mohammad Y, Fowkles A, Greenberg J, Nichols DS, Wolf SL, Good DC, Wittenberg GF. Motor Map Plasticity in Constraint Therapy for Stroke. Stroke, 2004; P164:284-285.
  17. Goldstein LB, Lenninhan L, Rabandi M, Good DC, Dromerick AW, Samsa GP and the AESR Investigators. Amphetamine-enhanced stroke recovery trial: Concurrent validity of the Stroke Impact Scale. Stroke 2005; 36:453.
  18. Greenberg JP, Butler AJ, Sawaki L, Schmalbrock P, Mao H, Nichols DS, Wolf SL, Wittenberg GF, Good DC. The effect of constraint-induced therapy for stroke on functional MRI motor maps. Society for Neuroscience Abstracts 2005; 30:431.7.
  19. Butler AJ, Ahmadian AA, KO J, Blanton S, Inkster D, Cavelheiro V, Sathian K, Wolf SL, Sawaki L, Wittenberg GF, Good DC. Can constraint-induced therapy improve upper extremity function and change TMS map parameters in hemiparetic patients? Society for Neuroscience Abstracts 2005; 30:431.8.
  20. Selected Peer Reviewed Papers:
  21. Reynolds PS, Gilbert L, Good DC, Knappertz VA, Crenshaw C, Wayne SL, Pillsbury D, Tegeler CH. Pneumonia in dysphagic stroke patients: Effect on outcomes and identification of high risk patients. J Neuro Rehab 1998;12:15-21.
  23. Bastings EP, Gage HD, Greenberg JP, Hammond G, Hernandez L, Santago P, Hamilton CA, Moody DM, Singh KD, Ricci PE, Pons TP, Good DC. Co-registration of cortical magnetic stimulation and functional magnetic resonance imaging. Neuro Report 1998; 9(9):1-6.
  24. Good DC, Viste KM. Neurologic rehabilitation at the end of the century in the United States. J Neuro Rehab 1998; 12:153-161.
  25. Maloney SR, Bell WL, Shoaf SC, Blair D, Bastings EP, Good DC, Quinlivan L. Measurement of lingual and palatine somatosensory evoked potentials. Clinical Neurophysiology 2000; 111:291-296.
  26. Gelber DA, Good DC, Dromerick A, Sergay S, Richardson M. Open-label-dose-filtration safety and efficacy study of tizanidine hydrochloride in the treatment of spasticity associated with chronic stroke. Stroke 2001; 32:1841-1846.
  27. Brashear A, Gordon M, Elovic E, Kassicieh V, Marciniak C, Do M, Lee C, Jenkins S, Turkel C, For the Botox Post-Stroke Study Group (David Good). Intramuscular injection of botulinum toxin for the treatment of wrist and finger spasticity after a stroke. N Engl J Med 2002; 347(6):395-400.
  28. Bastings E, Greenberg J, Good D. Hand motor recovery after stroke: a transcranial magnetic stimulation mapping study of motor output areas and their relation to functional status. Neurorehabilitation & Neural Repair 2002; 16:275-282.
  29. Yves V, Bastings E, Good DC, Rouiller E, Olivier E. Plasticitè des aires motrices corticales: Progrès rècents et perspectives thèrapeutiques. Rev Neurol March 2003; 159(3):259-275.
  30. Good DC, Stroke: promising neurorehabilitation interventions and steps towards testing them. Am J Phys Med Rehab 2003; 82(suppl):S50-S57.
  31. Weinrich M, Good D, Reding M, Roth EF, Cifu DX, Silver KH, Craik RL, Magaziner J, Terrin M, Axhwarz M, Gerber L. Timing, Intensity and Duration of Rehabilitation for Hip Fracture and Stroke. Report of a workshop at the National Center for Medical Rehabilitation Research. Neurorehabilitation and Neural Repair (in press).
  32. Childers MK, Brashear A, Jozefczyk P, Reding M, Alexander D, Good D, Walcott JM, Jenkins SW, Turkel C, Molloy P. Dose-Dependent Response to Intramuscular Botulinum Toxin Type A for Upper-Limb Spasticity in Patients After a Stroke. Arch Phys Med Rehabil 2004; 85(7):1063-1069.
  33. Foster D, Good DC, Fowlkes A, Sawaki L. Atomoxetine enhances a short-term model of plasticity in humans. 2005 Ann. Neurol (under review). Effect of stroke location. Stroke 2005; 36:428.
 

Back

 

College of Medicine    |    Medical Center    |    Children's Hospital

Privacy and Legal Notices

 

 

 

 

 

 



Penn State Milton S. Hershey Medical Center ©2004
This page was last updated on November 01, 2006
Contact Us