Faculty Biosketch
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Milton S. Hershey
Medical Center
Penn State College of Medicine
P.O. Box 850,
500 University Drive
Hershey, PA 17033-2390 |
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Thomas W. Gardner, M.D.
Department of Ophthalmology
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Office Information
Phone: 717-531-8783
Mail Code: HU19
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Education |
B.S., Penn State
University, 1975
M.D., Jefferson Medical College, 1979
M.S. (Physiology), Penn State University, 1998
Residency, Ophthalmology (Northwestern) 1980-83
Vitreoretinal diseases and surgery fellowship 1983-84,
Bascom Palmer Eye Institute, Miami, FL |
| Primary
Area of Interest |
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| Research
Focus |
| Dr. Gardner studies are focused on
understanding the basic biologic mechanisms that underlie
vision loss in diabetes. Specifically, he is
investigating the role of altered insulin receptor signaling
in the retina in diabetes and how modulation of this pathway
can lead to new therapies |
| References |
- Barber AJ, Lieth E, Khin S., Antonetti DA, Buchanan AG, Gardner TW.
Cell death in the neural retina during experimental and human diabetes:
early on set and effect of insulin. J Clin Invest 102:783-791, 1998.
- Antonetti DA, Barber AJ, Khin S, Lieth E, Gardner TW and the Penn
State Retina Research Group. Vascular permeability in experimental
diabetes is associated with reduced endothelial occludin content; occludin
expression is decreased in experimental diabetic retinopathy. Diabetes
47: 1953-1959, 1998.
- Gardner TW, Aiello LP. Pathogenesis of diabetic retinopathy.
In Flynn HF, Smiddy W (Eds). Diabetes and ocular disease: Past, Present,
and Future Therapies, American Academy of Ophthalmology monograph, pp
1-17, 2000.
- Antonetti DA, Barber AJ, Hollinger LA, Wolpert EB, Gardner TW and
the Penn State Retina Research Group. VEGF induces rapid occludin and
ZO-1 phosphorylation in retinal endothelial cells. A potential mechanism for
vascular permeability in diabetes and tumors. J Biol Chem 274:
23463-23467, 1999.
- Antonetti DA, Lieth E, Barber AJ, Gardner TW. Molecular
mechanisms of vascular permeability in diabetic retinopathy. Semin
Ophthalmol 14:240-248, 1999.
- Lieth E, Gardner TW, Barber AHm Antonetti DA and the Penn State
REtina Research Group. Retinal neurodegeneration: early pathology in
diabetes. Clin Exp Ophthalmolol 28: 3-8, 2000.
- Barber AJ, Antonetti DA, Gardner TW. Redistribution of glial
fibrillary acidic acid protein and occludin in the diabetic rat retina.
Invest Ophthalmol Vis Sci 41: 3561-3568, 2000.
- DeMaio L, Chang YS, Gardner TW, Tarbell JM, Antonetti DA. Shear
Stress regulates occludin content and phosphorylation. Am J Physiol,
281:H105-H113, 2001.
- Barber AJ, Nakamura, Reiter CEN, Wolpert EB, Antonetti DA, Gardner TW.
Insulin rescues retinal neurons from apoptosid by a phosphoinositol
3-kinase/Akt mediated mechanism that reduces the activation of caspase-3.
J Biol Chem 276:32815-32821, 2001.
- Nakamura M, Barber AJ, Antonetti DA, LaNoue KF, Robinson KA. Buse MG,
Gardner TW. Excessive hexosamines block the neuroprotective effect of
insulin and induces apoptosis in retinal neurons. J Biol Chem
276:43748-55, 2001.
- Reiter CEN, Gardner TW. Retinal insulin and insulin receptors:
implications for diabetic retinopathy. Prog Ret Eye Res 22:545-562,
2003.
- Yin S, Gardner TW, Thomas TO, Kolanda K. Light scatter causes the
grayness of detached retinas. Implications for visual loss in retinal
detachment. Arch Ophthalmol 121:1002-1008.
- Bronson SK, Reiter CEN, Gardner TW. An eye on insulin (invited
commentary). J Clin Invest 111:1817-1819, 2003.
- Reiter CEN, Sandirasegarane L, Wolpert EB, Klinger M, Simpson IA, Barber
AJ, Antonetti DA, Kester M, Gardner TW. Characterization of insulin
signaling in rat retina in vivo and ex vivo. Am J Physiol E763-E774,
2003.
- Wu X, Reiter CEN, Antonetti DA, Kimball SR, Jefferson LS, Gardner TW.
Insulin promotes rat retinal neuronal cell survival in a p70S6K-dependent
manner. J Biol Chem 279:9167-9175, 2004.
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