The Penn State MMPC is designed to provide the scientific community with unique,
state-of-the-art, and standardized experimental tools for the purpose of investigating
transgenic mouse models potentially useful for understanding obesity, diabetes and
its complications. The MMPC is composed of a multidisciplinary group of investigators
at the Penn State College of Medicine and consists of the following Phenotyping Cores:
- In Vivo Metabolism Core performs various non-invasive and
invasive procedures to measure whole body adiposity, glucose/lipid/protein metabolism, in individual organs, physical
activity, energy expenditure, and pancreatic β-cell function in awake mice.
- In Vitro Metabolism and Clinical Chemistry Core
conducts specialized experiments to measure
glucose/lipid/protein metabolism and mitochondrial/islet
function in isolated organs and applies biochemical
techniques to provide standardized measurement of
serum/urine/tissue factors obtained from mouse models of
diabetes and its complications.
- Complications Core consisting of
Cardiovascular Pathophysiology,
Retinopathy,
Nephropathy, and
Sleep & Behavior Sub-Cores
applies echocardiography, telemetry, EEG, and other in vivo and
in vitro techniques to assess cardiovascular, retinal, renal, and
sleep/behavior functions pertinent to diabetic complications.
- Functional Genomics and Proteomics Core
will apply PCR, whole genome microarray, 2D electrophoresis, and other state-of-the-art
methods to measure the expression of proteins and genes associated with obesity,
diabetes and its complications.
|
|
|
|
