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Vesicoureteral Reflux

What is it?

Vesicoureteral reflux occurs when urine flows from the bladder back into the ureters, and eventually into the kidneys. A ureter is a tube that normally carries urine from the kidney to the bladder, where it is held until it is released from the body. Each kidney has a ureter.

Who gets it?

Vesicoureteral reflux is usually seen in infants and children.

What causes it?

Vesicoureteral reflux can be caused by a structural defect, such as a ureter that did not grow to normal size during fetal development. When this occurs, the valve between the ureter and the bladder doesn’t close properly, allowed urine to reflux, or flow back, into the ureters. This is called primary vesicoureteral reflux. Other structural defects can include an abnormally large ureter at the point where it enters the bladder, a ureter that does not enter the bladder at the correct angle, and two ureters to one kidney. The condition is called secondary vesicoureteral reflux when it is caused by some type of blockage in the urinary system, such as a swollen ureter due to infection.

What are the symptoms?

Urine that travels back into the ureter can carry bacteria to the normally sterile kidneys. The resulting infection is what causes the symptoms of vesicoureteral reflux. Symptoms of infection include a burning sensation during urination, strong urge to urinate frequently, difficulty urinating, and blood or pus in the urine. There may also be abdominal and lower back pain, fever, chills, and nausea. As urine backs up, it places pressure on the kidney, which can eventually cause kidney damage. One symptom of kidney damage is high blood pressure. In younger children, parents may find difficulty with toilet training. Older children may wet the bed frequently.

How is it diagnosed?

To diagnose vesicoureteral reflux, your doctor will test for infection in a sample of your child’s urine. He or she will order diagnostic imaging studies of the child’s urinary system. Some of these may be done while the child urinates so the path from the ureters to the bladder can be seen. The severity of the vesicoureteral reflux is determined by the size and structure of the ureter and how far the urine is able to flow back toward the kidney.

What is the treatment?

Treatment for primary and secondary vesicoureteral reflux includes daily small doses of antibiotics to treat and prevent infection and kidney damage. Urine is tested on a regular basis to check for infection. Your doctor will also want to perform regular kidney exams to ensure the kidneys are growing properly and are undamaged. In some cases, primary vesicoureteral reflux may improve or go away with age because the ureter grows with the child. Surgery is recommended when reflux is severe, the ureters are not entering the bladder at the proper angle, kidneys are scarred or not growing normally, or there are other structural defects in the urinary system.

Self-care tips

At this time, there is no known way to prevent vesicoureteral reflux. If your child has been diagnosed with this condition, it is important to also check any brothers or sisters. It is not unusual for vesicoureteral reflux to occur in siblings. It is important to identify this condition before infection can damage the kidneys.


This information has been designed as a comprehensive and quick reference guide written by our health care reviewers.  The health information written by our authors is intended to be a supplement to the care provided by your physician.  It is not intended nor implied to be a substitute for professional medical advice. 

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This page was last updated on October 31, 2006
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