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Herpes Simplex and Zoster

Also known as:

  • Herpes Simplex type I (HSV-1), also known as cold sores or fever blisters
  • Herpes Simplex type II (HSV-2), also known as genital herpes
  • Herpes Zoster, also known as shingles

What is it?

Herpes is a skin infection.

Who gets it?

Anyone can get Herpes Simplex type I. Herpes Simplex type II appears in sexually active individuals. Herpes Zoster can occur in anyone who has had the chickenpox virus, but is more common in those over the age of 50.

What causes it?

HSV-1 is caused by the Herpes Simplex type I virus. It usually occurs with a viral illness, such as a cold, or at a time of stress. The Herpes Simplex type 2 virus causes HSV-2. Herpes Zoster is caused by the varicella zoster virus, which also causes chickenpox. Once you have been infected with a form of the herpes virus, the virus continues to live in the nerve cells of the skin or the central nervous system, but doesn't cause any symptoms. Something, such as an illness, stress, sunburn, or injury, can cause the virus to become active again, which causes the symptoms of HSV-1, HSV-2 or shingles. The virus may also occur in people who are taking drugs to suppress the immune system. Although shingles is not contagious, someone who hasn't had chickenpox can develop chickenpox if they have contact with fluid from a shingles blister. HSV-1 and HSV-2 are contagious and are spread by contact with the fluid in the blisters. HSV-2 is commonly spread through any type of sexual contact. HSV-2 can also be spread from a woman to the fetus if she becomes pregnant while infected with this virus.

What are the symptoms?

Herpes may begin with an initial tingling, burning, or numb sensation, followed by clusters of small, painful, fluid-filled blisters. HSV-1 blisters usually appear around the lips and surrounding skin. HSV-2 blisters appear on the genitals, around the anus, and on the buttocks. Within a few days, HSV-1 and -2 blisters are covered with a thin, yellow crust as they begin to dry, and the pain subsides. The blisters are gone within one to two weeks. Herpes Zoster often begins with a general feeling of sickness, including chills, fever, headache, fatigue, nausea, and diarrhea. Symptoms usually occur on one side of the face, back, or upper abdomen, which are the areas most commonly affected by chickenpox. The blisters follow a nerve path and usually appear in a line, most often on just one side of the back and spreading toward the abdomen. This area may be extremely sensitive to touch. After several days, the blisters begin to dry and scab. Some people develop the rash on one side of the face, which can also cause eye inflammation. All symptoms of shingles are usually gone within three to five weeks. However, some people may suffer nerve damage that causes pain to continue for months to years after the rash is gone. This condition is called post-herpetic neuralgia. HSV-1 and –2 symptoms can occur repeatedly, but most people get shingles only once in their lifetime.

How is it diagnosed?

To diagnose any form of herpes, your doctor will study your medical history and perform a physical examination. Laboratory tests, such a viral cultures and blood tests, can be performed to determine the type of virus causing the symptoms.

What is the treatment?

Herpes is treated with an antiviral medication that reduces symptoms and dries up the blisters. People who get HSV-1 or -2 frequently or have severe outbreaks may take this type of medication daily to prevent symptoms. Over-the-counter pain relievers, such as acetaminophen or ibuprofen, can help reduce pain. Cool compresses on the affected area may also provide relief. More severe pain may be relieved by prescription pain medications. In most people, shingles goes away on its own after it has run its course. Post-herpetic neuralgia is treated with tranquilizers, sedatives, or antidepressants that are taken at night. For all forms of herpes, it's important to keep your skin clean and dry so you don't develop any other types of infections in the blistered area. Your doctor might also prescribe some type of antibacterial ointment to help prevent infection. Severe infections, such as those involving the eyes, may be treated with corticosteroids drugs as well as antiviral therapy.

Self-care tips

You can help prevent HSV-1 and -2 by avoiding contact with herpes blisters if you have herpes or know someone who does. Wash your hands frequently, do not share food or drink, and do not touch a blister, then touch others or other areas of your body. Use sunscreen when outdoors to avoid sun-related outbreaks. As with any illness, it's important to get plenty of rest, follow a healthy diet, and reduce stress levels. If you have shingles, you should avoid contact with those who could contract chickenpox, especially newborns, the elderly, people with weakened immune systems, and pregnant women. People with a skin condition called atopic eczema should avoid any exposure to the herpes virus because it can develop into a possibly fatal condition called eczema herpeticum.
Contact your doctor if your symptoms become worse or if the blisters appear to be infected.


This information has been designed as a comprehensive and quick reference guide written by our health care reviewers.  The health information written by our authors is intended to be a supplement to the care provided by your physician.  It is not intended nor implied to be a substitute for professional medical advice. 

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This page was last updated on October 31, 2006
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