Primary Biliary Cirrhosis
What is it?
An inflammation of the bile ducts, leading to
obstruction of bile flow and damage to the liver
cells.
Who gets it?
Women are affected more often than men are. It
usually affects individuals aged 30 through 60
years old. May be associated with autoimmune
disorders.
What are the symptoms?
Symptoms may include itching, jaundice,
cholesterol deposits in the skin, and
discoloration of the skin. Softening of the bones
may occur in the late phase of the disease.
Diagnosis
Laboratory tests may indicate presence of
disease these include, elevation of alkaline
phosphatase, and mitochondrial antibody positive.
Endoscopic Retrograde Cholangiopancreatography or
ERCP is useful in diagnosis. Liver biopsy is also
useful in confirming the diagnosis.
Treatment
Treatment is aimed at controlling the symptoms
of the disease. Medications to control itching are
initiated. Vitamins are helpful to replace
deficiencies; calcium is initiated to help prevent
bone loss. Other medications are useful to aid in
bile flow. Liver Transplantation may be necessary
for progressive disease that leads to cirrhosis.
This information has been designed as a comprehensive and quick reference
guide written by our health care reviewers. The health information written
by our authors is intended to be a supplement to the care provided by your
physician. It is not intended nor implied to be a substitute for
professional medical advice.
|
