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Bipolar Disorder

Also known as:  Manic-depressive disorder

What is it?

Bipolar disorder is a serious mental illness marked by mood shifts and episodes of depression and mania. The Diagnostic and Statistical Manual of Mental Disorders lists four separate categories of bipolar disorder: bipolar I, bipolar II, cyclothymia, and bipolar not-otherwise-specified (NOS).

Bipolar I is marked by manic episodes followed by periods of depression that may not be severe. In contrast, Bipolar II is marked by major depressive episodes and hypomanic periods, or milder episodes of mania. Cyclothymia is defined as episodes of hypomania and depressive periods that do not reach major depressive proportions. Bipolar NOS means that the bipolar state does not fit into the other categories.

Who gets it?

Both children and adults may develop bipolar disorder but most commonly, the disorder develops from adolescence through the early twenties. Studies have shown that people who have family members with emotional disorders may be more susceptible to bipolar disorder. Many patients with bipolar disorder have a history of substance abuse. A possible biological cause is the presence of calcium build-up in the cells of bipolar patients. Bipolar disorder is just as prevalent among women as men although their symptoms may vary.

What causes it?

There is no clear cause of bipolar disorder. It may be genetic, the result of substance abuse – especially cocaine – or caused by the presence of calcium build-up in the cells.

What are the symptoms?

An adult with bipolar disorder will have unusual or extreme shifts in mood, energy and behavior that could interfere significantly with normal life.

Manic symptoms include: extreme irritability or silliness, very high self-esteem, increased energy, decreased need for sleep, talking quickly and allowing no interruptions, hypersexuality, increased goal-directed activity, risk-taking, and distraction.

Depressive symptoms include: persistent sadness or irritability, loss of interest, significant change in appetite or body weight, difficulty sleeping or excessive sleeping, loss of energy, feelings of worthlessness or inappropriate guilt, difficulty concentrating, suicidal thoughts.

Some bipolar patients’ episodes may coincide with seasonal changes, having manic episodes in spring and summer months and depressive episodes in fall and winter.

Diagnosis

A psychiatrist or psychologist usually diagnoses bipolar disorder. Interviews and tests may be used and, because of the complexity of the disorder, it may take several visits, and sometimes months or years, to definitively diagnose a patient with bipolar disorder.

Treatment

Bipolar disorder is treated with medications including a combination of mood stabilizing agents, anti-depressants, anti-psychotics and anticonvulsants. An individualized combination of the medications is determined in order to regulate the patient’s manic and depressive episodes. Psychotherapy and counseling may be used in combination with medications.

Electroconvulsive therapy can be used as a treatment for unipolar and bipolar depression and mania. Because of the stigma attached to ECT, it is often used after medication options are explored. ECT is given under anesthesia and muscle relaxants are used to prevent convulsions. The exact reasons ECT works is unknown, but it seems that the electrical currents sent to the brain alter the electrochemical processes of the brain and, consequently, relieve depression.

Whereas many patients respond to medications, ECT and psychotherapy, a small number of those suffering with bipolar disorder don’t respond to any treatments. Generally, bipolar disorder requires lifelong treatment.


This information has been designed as a comprehensive and quick reference guide written by our health care reviewers.  The health information written by our authors is intended to be a supplement to the care provided by your physician.  It is not intended nor implied to be a substitute for professional medical advice. 

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This page was last updated on October 31, 2006
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