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Research at The
Penn State College of Medicine is supported by an outstanding suite of research
facilities including:
General
Clinical Research Center
Core
Research facilities
Animal
Facilities
The
GCRC is a 6,800 square feet unit that includes five patient exam rooms, three
infusion/sleep rooms, an exercise room, and a micro dialysis core lab.
This facility, which has been recently renovated, has been funded by the
NIH since 1995. It provides an
ideal infrastructure for investigators who conduct research with human subjects.
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Research
at The Penn State College of Medicine is supported by an extensive suite of core
facilities.
oligonucleotides
synthesis, peptide synthesis, peptide sequencing, image analysis,
absorbance/fluorescence plate scanner
Research
and clinical FACScan analysis; cytomation MoFlo high speed cell sorting
Production
of transgenic and knockout mice
DNA
sequencing from plasmids, PCR products, and BACs; sequence analysis programs,
SEQWeb and the GCG/Wisconsin package.
DNA
microarray facility; quantitative real-time PCR; custom DNA array production,
real-time PCR
Confocal,
deconvolution, fluorescent, and electron microscopy; histology services
Mass
spectroscopic analyses of proteins, peptides, small molecules; 2D LC separations
of complex mixtures for proteomics; protein expression analysis using ICAT
methodology
Molecular
modeling using the Insight II or MOE programs; Docking software; 3D
visualization with Stereo glasses; molecular dynamics simulations
Shared
resources available to investigators at the College of Medicine include:
Provides
access to banked tumor and normal tissue specimens
Discounted
products from seven vendors of cell biology, cell culture, and molecular biology
reagents and supplies are available on site
Additional
shared resources, including a monoclonal hybridoma facility are available
through the Penn State Huck
Institutes for Life Sciences Shared Technology Facilities at the
University Park campus.
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The
Animal Resource Facility, which includes the Central Animal Quarters in the
Medical Sciences Building, an Animal Research Farm, and a large dairy barn with
acreage for pastures and corrals, has been designated by national agencies as a
model research facility with respect to both design and operation.
The
Animal Research Farm has designated space for quarantine, holding, and
breeding of a wide variety of species ranging from small laboratory animals
through nonhuman primates. The facility is ideal for long-term observation of
animals under chronic experimentation by providing better genetic control and
conditioning. Interconnected units include administration, research, training,
quarantine/holding (for small and large animals, primates, dogs), service core
facilities, and experimental surgery. A new 8,159 sq. ft. addition for housing
transgenic animals at the Animal Research Farm was opened in the fall of 2002.
The new wing is designed to operate as a barrier utilizing structural factors
and procedures to prevent the introduction of infectious diseases into the
animals housed there.
The Central Animal Quarters of
the Animal Resource Facility, located on the ground floor of the Basic Sciences
Wing, is designed for teaching and experimentation. This unit includes surgical
suites and holding areas for smaller species. It also has specially designed
facilities for infectious diseases (BSL3), radioisotopes, diagnostic and
experimental radiology, diagnostic laboratories (histopathology, clinical
chemistry, and microbiology), and small animal colonies. These facilities permit
intensive study at the cellular and subcellular levels of basic biologic
phenomena on a variety of domestic and exotic laboratory animals. The Animal
Research Farm is connected to the Central Animal Quarters by a 1400-foot tunnel.
This tunnel permits movement of animals between the two units under controlled
environmental conditions.
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